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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Epilepsy as progressive disorders: What is the evidence that can guide our clinical decisions and how can neuroimaging help?

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Autor(es):
Coan, Ana C. [1] ; Cendes, Fernando [1]
Número total de Autores: 2
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Neuroimaging Lab, Dept Neurol, BR-13083970 Campinas, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo de Revisão
Fonte: Epilepsy & Behavior; v. 26, n. 3, p. 313-321, MAR 2013.
Citações Web of Science: 13
Resumo

There is evidence that some types of epilepsy progress over time, and an important part of this knowledge has derived from neuroimaging studies. Different authors have demonstrated structural damage more pronounced in individuals with a longer duration of epilepsy, and others have been able to quantify this progression over time. However, others have failed to demonstrate progression possibly due to the heterogeneity of individuals evaluated. Currently, temporal lobe epilepsy associated with hippocampal sclerosis is regarded as a progressive disorder. Conversely, for other types of epilepsy, the evidence is not so clear. The causes of this damage progression are also unknown although there is consistent evidence that seizure is one of the mechanisms. The conflicting data about epilepsy progression can be a challenge for clinical decisions for an individual patient. Studies with homogenous groups and longer follow-up are necessary for appropriate conclusions about the real burden of damage progression in epilepsies, and neuroimaging will be essential in this context. This article is part of a Special Issue entitled ``The Future of Translational Epilepsy Research{''}. (C) 2012 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 09/54552-9 - Estudo da progressão de dano na epilepsia de lobo temporal mesial com ou sem sinais de esclerose hipocampal
Beneficiário:Ana Carolina Coan
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 05/56578-4 - Centro multimodal de neuroimagens para estudos em epilepsia
Beneficiário:Fernando Cendes
Linha de fomento: Auxílio à Pesquisa - Programa CINAPCE - Temático