Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Enhanced nicotine-seeking behavior following pre-exposure to repeated cocaine is accompanied by changes in BDNF in the nucleus accumbens of rats

Texto completo
Autor(es):
Leao, Rodrigo M. [1, 2] ; Cruz, Fabio C. [1] ; Carneiro-de-Oliveira, Paulo E. [1, 2] ; Rossetto, Daniella B. [3] ; Valentini, Sandro R. [3] ; Zanelli, Cleslei F. [3] ; Planeta, Cleopatra S. [1, 2]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista UNESP, Pharmacol Lab, Sch Pharmaceut Sci, BR-14801902 Sao Paulo - Brazil
[2] Joint Grad Program Physiol Sci UFSCar UNESP, Sao Paulo - Brazil
[3] UNESP Univ Estadual Paulista, Dept Biol Sci, Sch Pharmaceut Sci, Araraquara, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Pharmacology Biochemistry and Behavior; v. 104, p. 169-176, MAR 2013.
Citações Web of Science: 7
Resumo

We investigated the behavioral and molecular interactions between cocaine and nicotine, through evaluating locomotor activity, nicotine intravenous self-administration and gene expression. Locomotor sensitization was induced in male Wistar rats by repeated cocaine (20 mg/kg; i.p.) or saline injections once a day over 7 days. Three days after the last injection, rats were challenged with either saline or cocaine (15 mg/kg; i.p.) and the locomotor activity was measured. The very next day animals received either saline or nicotine (0.4 mg/kg; s.c.) and the locomotor cross-sensitization was tested. Animals were then prepared with intrajugular catheters for nicotine self-administration. Nicotine self-administration patterns were evaluated using fixed or progressive ratio schedules of reinforcement and a 24-h unlimited access binge. Immediately after the binge sessions animals were decapitated, the brains were removed and the nucleus accumbens was dissected. The dynorphin (DYN), mu-opioid receptor (mu opioid), neuropeptide Y (NPY), brain-derived neurotrophic factor (BDNF), tropomyosin-related tyrosine kinase B receptor (TrkB) and corticotropin-releasing factor receptor type 1 (CRF-R1) gene expression were measured by the reverse transcription-polymerase chain reaction (RT-PCR). Pretreatment with cocaine caused sensitization of cocaine motor response and locomotor cross-sensitization with nicotine. In the self-administration experiments repeated cocaine administration caused an increase in the nicotine break point and nicotine intake during a 24 h binge session. (C) 2013 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 07/57541-2 - Efeitos da cafeína na transmissão serotonérgica e dopaminérgica em ratos adultos e adolescentes
Beneficiário:Ana Paula Marques Possi
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 08/10691-2 - Estresse crônico e auto-administração de nicotina: envolvimento da via de transdução PKA, CREB e ERK no núcleo acumbens e córtex pré-frontal
Beneficiário:Rodrigo Molini Leão
Linha de fomento: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 11/07469-9 - Interação entre etanol e nicotina ao longo da ontogênese: avaliação de parâmetros da autoadministração e expressão gênica no sistema mesocorticolímbico
Beneficiário:Cleopatra da Silva Planeta
Linha de fomento: Auxílio à Pesquisa - Regular