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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Natural Products as a Source for Treating Neglected Parasitic Diseases

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Autor(es):
Ndjonka, Dieudonne [1] ; Rapado, Ludmila Nakamura [2] ; Silber, Ariel M. [2] ; Liebau, Eva [3] ; Wrenger, Carsten [2]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Ngaoundere, Fac Sci, Dept Biol Sci, Ngaoundere - Cameroon
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Unit Drug Discovery, BR-05508000 Sao Paulo - Brazil
[3] Inst Zoophysiol, D-48143 Munster - Germany
Número total de Afiliações: 3
Tipo de documento: Artigo de Revisão
Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 14, n. 2, p. 3395-3439, FEB 2013.
Citações Web of Science: 76
Resumo

Infectious diseases caused by parasites are a major threat for the entire mankind, especially in the tropics. More than 1 billion people world-wide are directly exposed to tropical parasites such as the causative agents of trypanosomiasis, leishmaniasis, schistosomiasis, lymphatic filariasis and onchocerciasis, which represent a major health problem, particularly in impecunious areas. Unlike most antibiotics, there is no ``general{''} antiparasitic drug available. Here, the selection of antiparasitic drugs varies between different organisms. Some of the currently available drugs are chemically de novo synthesized, however, the majority of drugs are derived from natural sources such as plants which have subsequently been chemically modified to warrant higher potency against these human pathogens. In this review article we will provide an overview of the current status of plant derived pharmaceuticals and their chemical modifications to target parasite-specific peculiarities in order to interfere with their proliferation in the human host. (AU)

Processo FAPESP: 11/50631-1 - Metabolismo de histidina: o papel da via histina-glutamato na biologia do Trypanosoma cruzi
Beneficiário:Ariel Mariano Silber
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/54325-2 - Elucidation of vitamin B metabolism in the human malaria parasite Plasmodium falciparum and their validation as a target for chemotherapy
Beneficiário:Carsten Wrenger
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores