Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Differences and Similarities among Parotoid Macrogland Secretions in South American Toads: A Preliminary Biochemical Delineation

Texto completo
Autor(es):
Sciani, Juliana Mozer [1] ; Angeli, Claudia Blanes [2] ; Antoniazzi, Marta M. [3] ; Jared, Carlos [3] ; Pimenta, Daniel Carvalho [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Inst Butantan, Lab Bioquim & Biofis, BR-05503900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, BR-05508000 Sao Paulo - Brazil
[3] Inst Butantan, Lab Biol Celular, BR-05503900 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: SCIENTIFIC WORLD JOURNAL; 2013.
Citações Web of Science: 26
Resumo

Amphibians are known by cutaneous glands, spread over the skin, containing toxins (proteins, peptides, biogenic amines, steroidal bufadienolides, and alkaloids) used as chemical defense against predators and microbial infection. Toads are characterized by the presence of parotoid macroglands. The common toads have lately been divided into two genera: Bufo (Europe, Asia, and Africa) and Rhinella (South America). Basal Rhaebo genus is exclusively of Central America and Amazon region. Although Rhinella and Rhaebo are related, species may share differences due to the diversity of environments that they live in. In this work, we have performed a biochemical characterization of the components of the poison of eight Rhinella species and one Rhaebo by means of RP-HPLC with either UV or MS detection and by SDS-PAGE, in order to verify whether phylogenetic and biological differences, such as habitat, diet, and defensive strategies, between them may also be reflected in poison composition. Although some components were common among the secretions, we were able to identify exclusive molecules to some species. The fact that closely related animals living in different habitats secrete different molecules into the skin is an indication that biological features, and not only evolution, seem to directly influence the skin secretion composition. (AU)

Processo FAPESP: 07/02476-1 - Identificação e caracterização bioquímica de peptídeos e proteínas na secreção cutânea de Chaunus jimi (Bufonidae, Anura, Amphibia)
Beneficiário:Daniel Carvalho Pimenta
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 07/08478-6 - Isolamento e caracterização bioquímica de peptídeos e proteínas de Echinometra lucunter monitorado por efeito biológico.
Beneficiário:Juliana Mozer Sciani
Linha de fomento: Bolsas no Brasil - Doutorado