Rhenium mixed-ligand complexes with S,N, S-tridentate thiosemicarbazone/thiosemicarbazide ligands

Autor(es)

Maia, Pedro I. da S. ^[1] ; Nguyen, Hung Huy ^[2] ; Hagenbach, Adelheid ^[3] ; Bergemann, Silke ^[4] ; Gust, Ronald ^[5] ; Deflon, Victor M. ^[1] ; Abram, Ulrich ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim Sao Carlos, Sao Carlos, SP - Brazil

^[2] Hung Huy Nguyen, Hanoi Univ Sci, Dept Chem, Hanoi - Vietnam

^[3] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin - Germany

^[4] Free Univ Berlin, Inst Pharm, D-14195 Berlin - Germany

^[5] Univ Innsbruck, Inst Pharm, A-6020 Innsbruck - Austria

• Tipo de documento: Artigo Científico
• Fonte: DALTON TRANSACTIONS; v. 42, n. 14, p. 5111-5121, 2013.
• Citações Web of Science: 15

Resumo

Rhenium(V) complexes containing tridentate thiosemicarbazones/thiosemicarbazides (H(2)L1) derived from N-{[}N', N'-dialkylamino(thiocarbonyl)] benzimidoyl chlorides with 4,4-dialkylthiosemicarbazides have been synthesized by ligand-exchange reactions starting from {[}ReOCl(L1)]. The chlorido ligand of {[}ReOCl-(L1)] (4) is readily replaced and reactions with ammonium thiocyanate or potassium cyanide give {[}ReO-(NCS)(L1)] (6) and {[}ReO(CN)(L1)] (7), respectively. The reaction of (NBu4){[}ReOCl4] with H(2)L1 and two equivalents of ammonium thiocyanate, however, gives in a one-pot reaction {[}ReO(NCS)(2)(HL1)] (8), in which the pro-ligand H(2)L1 is only singly deprotonated. An oxo-bridged, dimeric nitridorhenium(V) compound of the composition {[}[ReN(HL1)](2)O] (11) is obtained from a reaction of (NBu4){[}ReOCl4], H(2)L1 and sodium azide. The six-coordinate complexes {[}ReO(L1)(Ph(2)btu)] (12), where HPh2btu is N, N-diphenyl-N'-benzoylthiourea, can be obtained by treatment of {[}ReOCl(L1)] with HPh(2)btu in the presence of NEt3. Studies of the antiproliferative effects of the {[}ReOX(L1)] system (X = Cl-, NCS- or CN-) on breast cancer cells show that the lability of a monodentate ligand seems to play a key role in the cytotoxic activity of the metal complexes, while the substitution of this ligand by the chelating ligand Ph(2)btu(-) completely terminates the cytotoxicity. (AU)

• Processo FAPESP: 11/16380-1 - Complexos de Au, Re e Tc com tiossemicarbazonas de interesse no desenvolvimento de fármacos ou radiofármacos para diagnóstico ou terapia
• Beneficiário: Pedro Ivo da Silva Maia
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado