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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Exercise and Caloric Restriction Alter the Immune System of Mice Submitted to a High-Fat Diet

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Autor(es):
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Wasinski, Frederick [1] ; Bacurau, Reury F. P. [2] ; Moraes, Milton R. [1] ; Haro, Anderson S. [1] ; Moraes-Vieira, Pedro M. M. [3] ; Estrela, Gabriel R. [1] ; Paredes-Gamero, Edgar J. [1] ; Barros, Carlos C. [4] ; Almeida, Sandro S. [1] ; Camara, Niels O. S. [3] ; Araujo, Ronaldo C. [1]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Biophys, BR-04023062 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Arts Sci & Humanities, BR-03828000 Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Lab Transplantat Immunobiol, Dept Immunol, BR-05508900 Sao Paulo - Brazil
[4] Univ Fed Pelotas, Sch Nutr, Dept Nutr, BR-96010610 Pelotas, RS - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Mediators of Inflammation; 2013.
Citações Web of Science: 19
Resumo

As the size of adipocytes increases during obesity, the establishment of resident immune cells in adipose tissue becomes an important source of proinflammatory mediators. Exercise and caloric restriction are two important, nonpharmacological tools against body mass increase. To date, their effects on the immune cells of adipose tissue in obese organisms, specifically when a high-fat diet is consumed, have been poorly investigated. Thus, after consuming a high-fat diet, mice were submitted to chronic swimming training or a 30% caloric restriction in order to investigate the effects of both interventions on resident immune cells in adipose tissue. These strategies were able to reduce body mass and resulted in changes in the number of resident immune cells in the adipose tissue and levels of cytokines/chemokines in serum. While exercise increased the number of NK cells in adipose tissue and serum levels of IL-6 and RANTES, caloric restriction increased the CD4+/CD8+ cell ratio and MCP-1 levels. Together, these data demonstrated that exercise and caloric restriction modulate resident immune cells in adipose tissues differently in spite of an equivalent body weight reduction. Additionally, the results also reinforce the idea that a combination of both strategies is better than either individually for combating obesity. (AU)

Processo FAPESP: 11/03528-0 - Papel do treinamento físico na modulação da inflamação do tecido adiposo de camundongos obesos
Beneficiário:Ronaldo de Carvalho Araújo
Linha de fomento: Auxílio à Pesquisa - Regular