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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Reduction in the Leptin Concentration as a Predictor of Improvement in Lung Function in Obese Adolescents

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Autor(es):
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da Silva, Patricia Leao [1] ; de Mello, Marco Tulio [2] ; Cheik, Nadia Carla ; Sanches, Priscila Lima [1] ; da Silveira Campos, Raquel Munhoz [1] ; Carnier, June [1] ; Inoue, Daniela [1] ; do Nascimento, Claudia M. O. [3] ; Oyama, Lila M. [4] ; Tock, Lian [1] ; Tufik, Sergio [3] ; Damaso, Ana R. [5, 1, 6]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Post Grad Program Nutr, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo - Brazil
[4] Univ Fed Uberlandia, BR-38400 Uberlandia, MG - Brazil
[5] Univ Fed Sao Paulo, Dept Biosci, Sao Paulo - Brazil
[6] Univ Fed Sao Paulo, Post Grad Program Interdisciplinary Hlth Sci, Sao Paulo - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: Obesity Facts; v. 5, n. 6, p. 806-820, DEC 2012.
Citações Web of Science: 13
Resumo

Objective: To assess the effects of weight loss on adipokines, asthma-related symptoms, exercise-induced bronchospasm (EIB) and lung function, and to evaluate the role of leptin and adiponectin levels on lung function after treatment in obese adolescents. Methods: 84 postpubertal obese adolescents were enrolled and distributed in quartiles according to weight loss (low (<2.5 kg), low to moderate (>2.5 and <8 kg), moderate (<8 and <14 kg) and massive (<14 kg)). Body composition was measured by plethysmography, and visceral and subcutaneous fat were detected by ultrasound. Serum levels of adiponectin and leptin were analyzed. Lung function, asthma and EIB were evaluated according to the American Thoracic Society criteria. Patients were submitted to 1 year of interdisciplinary intervention consisting of physiotherapy, medical, nutritional, exercise, and psychological therapy. Results: After treatment the moderate and massive weight loss promoted an increase in adiponectin and adiponectin/leptin (A/L) ratio as well as a decrease in leptin levels and a reduction in EIB frequency and asthma-related symptoms. Furthermore, the reduction in leptin levels was a predictor factor to improvement in lung function. Conclusion: Interdisciplinary therapy was able to decrease EIB and asthma-related symptoms and to improve pro/anti-inflammatory adipokines. Additionally, the leptin concentration was a predictor factor to explain changes in lung function. Copyright (C) 2012 S. Karger AG, Basel (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 06/00684-3 - Fatores orexígenos, anorexígenos, pró e anti-inflamatórios: efeitos do programa multidisciplinar para redução da massa corporal em adolescentes obesos
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/53069-0 - Efeitos do tratamento multidisciplinar em adolescentes obesos com esteatose hepática não alcoólica e sua relação com as adipocitocinas pró e anti-inflamatórias
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular