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(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Significant differences in demographic, clinical, and pathological features in relation to smoking and alcohol consumption among 1,633 head and neck cancer patients

Texto completo
Autor(es):
Moyses, Raquel Ajub [1] ; Lopez, Rossana Veronica Mendoza [2] ; Cury, Patricia Maluf [3] ; Siqueira, Sheila Aparecida Coelho [4] ; Curioni, Otavio Alberto [5] ; Filho, Jose Francisco de Gois [6] ; Figueiredo, David Livingstone Alves [7] ; Tajara, Eloiza Helena [8] ; Michaluart, Jr., Pedro [9] ; GENCAPO, Head Neck Genome Project [6]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med, Hosp Clin, Disciplina Cirurg Cabec & Pescoc LIM28, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, Sao Paulo - Brazil
[3] Fac Med Sao Jose Rio Preto, Dept Patol & Med Legal, Sao Jose Do Rio Preto, SP - Brazil
[4] Univ Sao Paulo, Fac Med, Hosp Clin, Dept Patol, Sao Paulo - Brazil
[5] Hosp Heliopolis, Dept Otorrinolaringol Cirurg & Cabeca Pescoc, Sao Paulo - Brazil
[6] Head Neck Genome Project GENCAPO, Projeto temat FAPESP, Sao Paulo - Brazil
[7] Fac Med Ribeirao Preto, Dept Oftalmol Otorrinolaringol & Cirurg Cabeca Pe, Ribeirao Preto, SP - Brazil
[8] Fac Med Sao Jose Rio Preto, Dept Biol Mol, Sao Jose Do Rio Preto - Brazil
[9] Inst Invest Imunol, Sao Paulo - Brazil
Número total de Afiliações: 9
Tipo de documento: Artigo Científico
Fonte: Clinics; v. 68, n. 6, p. 738-744, Jun. 2013.
Citações Web of Science: 6
Resumo

OBJECTIVE: As a lifestyle-related disease, social and cultural disparities may influence the features of squamous cell carcinoma of the head and neck in different geographic regions. We describe demographic, clinical, and pathological aspects of squamous cell carcinoma of the head and neck according to the smoking and alcohol consumption habits of patients in a Brazilian cohort. METHODS: We prospectively analyzed the smoking and alcohol consumption habits of 1,633 patients enrolled in five São Paulo hospitals that participated in the Brazilian Head and Neck Genome Project - Gencapo. RESULTS: The patients who smoked and drank were younger, and those who smoked were leaner than the other patients, regardless of alcohol consumption. The non-smokers/non-drinkers were typically elderly white females who had more differentiated oral cavity cancers and fewer first-degree relatives who smoked. The patients who drank presented significantly more frequent nodal metastasis, and those who smoked presented less-differentiated tumors. CONCLUSIONS: The patients with squamous cell carcinoma of the head and neck demonstrated demographic, clinical, and pathological features that were markedly different according to their smoking and drinking habits. A subset of elderly females who had oral cavity cancer and had never smoked or consumed alcohol was notable. Alcohol consumption seemed to be related to nodal metastasis, whereas smoking correlated with the degree of differentiation. (AU)

Processo FAPESP: 04/12054-9 - Busca de marcadores de agressividade em tumores de cabeça e pescoço
Beneficiário:Eloiza Helena Tajara da Silva
Linha de fomento: Auxílio à Pesquisa - Temático