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Effects of the administration of a catalase inhibitor into the fourth cerebral ventricle on cardiovascular responses in spontaneously hypertensive rats exposed to sidestream cigarette smoke

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Autor(es):
Valenti, Vitor E. [1] ; de Abreu, Luiz Carlos [2] ; Fonseca, Fernando L. A. [2] ; Adami, Fernando [2] ; Sato, Monica A. ; Vanderlei, Luiz Carlos M. [1] ; Ferreira, Lucas Lima [1] ; Rodrigues, Luciano M. [2] ; Ferreira, Celso [3]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista UNESP, Fac Ciencias & Tecnol, Programa Posgrad Fisioterapia, Presidente Prudente, SP - Brazil
[2] Fac Med ABC, Dept Morfol & Fisiol, Santo Andre, SP - Brazil
[3] Univ Fed Sao Paulo UNIFESP, Programa Posgrad Cardiol, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Clinics; v. 68, n. 6, p. 851-857, Jun. 2013.
Citações Web of Science: 3
Resumo

OBJECTIVE: Previous studies have demonstrated a relationship between brain oxidative stress and cardiovascular regulation. We evaluated the effects of central catalase inhibition on cardiovascular responses in spontaneously hypertensive rats exposed to sidestream cigarette smoke. METHODS: Male Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (SH) (16 weeks old) were implanted with a stainless steel guide cannula leading into the fourth cerebral ventricle (4th V). The femoral artery and vein were cannulated for arterial pressure and heart rate measurement and drug infusion, respectively. The rats were exposed to sidestream cigarette smoke for 180 minutes/day, 5 days/week for 3 weeks (CO: 100-300 ppm). The baroreflex was tested using a pressor dose of phenylephrine (8 μg/kg, bolus) and a depressor dose of sodium nitroprusside (50 μg/kg, bolus). Cardiovascular responses were evaluated before and 5, 15, 30 and 60 minutes after injection of a catalase inhibitor (3-amino-1,2,4-triazole, 0.001 g/100 μL) into the 4th V. RESULTS: Vehicle administration into the 4th V did not affect the cardiovascular response, whereas administration of the central catalase inhibitor increased the basal HR and attenuated the bradycardic peak (p<0.05) to a greater extent in WKY rats exposed to sidestream cigarette smoke than in WKY rats exposed to fresh air. However, in spontaneously hypertensive rats, the effect of the catalase inhibitor treatment was stronger in the fresh air condition (p<0.05). CONCLUSION: Administration of a catalase inhibitor into the 4th V combined with exposure to sidestream cigarette smoke has a stronger effect in WKY rats than in SH rats. (AU)

Processo FAPESP: 10/17769-7 - Efeitos agudos da exposição à fumaça lateral de cigarro e ao material particulado sobre a modulação autonômica do sistema cardiovascular
Beneficiário:Vitor Engrácia Valenti
Linha de fomento: Bolsas no Brasil - Pós-Doutorado