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Insulin-like growth factor 1 gene (CA)n repeats and a variable number of tandem repeats of the insulin gene in Brazilian children born small for gestational age

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Autor(es):
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Coletta, Rocio R. D. [1] ; Jorge, Alexander A. L. [1] ; D' Alva, Catarina Brasil [1] ; Pinto, Emilia M. [1] ; Billerbeck, Ana Elisa C. [1] ; Pachi, Paulo R. [2] ; Longui, Carlos A. [3] ; Garcia, Ricardo M. [3] ; Boguszewski, Margaret [4] ; Arnhold, Ivo J. P. [1] ; Mendonca, Berenice B. [1] ; Costa, Elaine M. F. [1]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med, Hosp Clin, Unidade Endocrinol Desenvolvimento, Lab Hormonios, Sao Paulo - Brazil
[2] Santa Casa Sao Paulo, Sao Paulo - Brazil
[3] Santa Casa Misericordia Sao Paulo, Unidade Endocrinol Pediatr, Sao Paulo - Brazil
[4] Hosp Clin Curitiba, Unidade Endocrinol Pediatr, Curitiba, PR - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Clinics; v. 68, n. 6, p. 785-791, Jun. 2013.
Citações Web of Science: 2
Resumo

OBJECTIVE: To investigate the influence of (CA)n repeats in the insulin-like growth factor 1 gene and a variable number of tandem repeats of the insulin gene on birth size in children who are small or adequate-sized for gestational age and to correlate these polymorphisms with serum insulin-like growth factor 1 levels and insulin sensitivity in children who are small for gestational age, with and without catch-up growth. PATIENTS AND METHODS: We evaluated 439 infants: 297 that were adequate-sized for gestational age and 142 that were small for gestational age (66 with and 76 without catch-up). The number of (CA)n repeat in the insulin-like growth factor 1 gene and a variable number of tandem repeats in the insulin gene were analyzed using GENESCAN software and polymerase chain reaction followed by enzymatic digestion, respectively. Clinical and laboratory data were obtained from all patients. RESULTS: The height, body mass index, paternal height, target height and insulin-like growth factor 1 serum levels were higher in children who were small for gestational age with catch-up. There was no difference in the allelic and genotypic distributions of both polymorphisms between the adequate-sized and small infants or among small infants with and without catch-up. Similarly, the polymorphisms were not associated with clinical or laboratory variables. CONCLUSION: Polymorphisms of the (CA)n repeats of the insulin-like growth factor 1 gene and a variable number of tandem repeats of the insulin gene, separately or in combination, did not influence pre- or postnatal growth, insulin-like growth factor 1 serum levels or insulin resistance. (AU)

Processo FAPESP: 05/50093-9 - Estudo do VNTR do gene da insulina, região promotora P3 do gene do IGF2 e repetições CA do gene do IGF1 em indivíduos nascidos pequenos para a idade gestacional com e sem recuperação estatural associada ou não à hipospádia
Beneficiário:Rocio Riatto Della Coletta
Linha de fomento: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 05/04726-0 - Caracterização molecular das doenças endócrinas congênitas que afetam o crescimento e o desenvolvimento
Beneficiário:Ana Claudia Latronico Xavier
Linha de fomento: Auxílio à Pesquisa - Temático