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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Sagittal abdominal diameter as a marker for epicardial adipose tissue in premenopausal women

Texto completo
Autor(es):
Junqueira Vasques, Ana Carolina [1] ; Matos Souza, Jose Roberto [1] ; Yamanaka, Ademar [1] ; de Oliveira, Maria da Saude [1] ; Novaes, Fernanda Satake [1] ; Pareja, Jose Carlos [1] ; Geloneze, Bruno [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Dept Internal Med, Sch Med, Lab Invest Metab & Diabet LIMED, Campinas, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: METABOLISM-CLINICAL AND EXPERIMENTAL; v. 62, n. 7, p. 1032-1036, JUL 2013.
Citações Web of Science: 6
Resumo

Objective. Accumulation of epicardial (EAT) adipose tissue is associated with the development of an unfavorable metabolic risk profile. Gold standard methods used to assess this fat depot are not routinely applicable in the clinic. Anthropometric measures, including the sagittal abdominal diameter (SAD), have emerged as surrogate markers of visceral obesity. We determined the relationship between EAT measurement and cardiometabolic risk parameters and the potential use of the SAD, compared with other anthropometric parameters, as a practical estimation of EAT. Materials/Methods. Sixty-seven premenopausal women were evaluated. The anthropometric parameters that were measured included waist circumference, SAD, body mass index and waist-to-hip ratio. EAT was determined by echocardiogram. Visceral adipose tissue (VAT) was determined by abdominal ultrasound. Insulin sensitivity was assessed by the hyperglycemic clamp. Results. The accumulation of EAT was correlated with impaired insulin sensitivity and decreased adiponectin. All of the anthropometric measurements were correlated with EAT. Interestingly, EAT was most significantly correlated with the SAD. From the ROC analysis, we found that the SAD measurements were very accurate, presenting the highest area under the curve for EAT (0.81; p<0.01) when compared with the other measurements. In the multiple linear regression analysis, EAT was moderately predicted by the SAD (R-2=0.25; p<0.001). Conclusion. SAD, a simple anthropometric measure, accurately estimated EAT and thus represents a clinically useful non-invasive marker that can identify patients with EAT accumulation. (C) 2013 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 08/07312-0 - Capacidade secretória de insulina em pacientes saudáveis, em obesos, em obesos diabéticos tipo 2 e em obesos diabéticos tipo 2 submetidos à cirurgia bariátrica através do clamp hiperglicêmico
Beneficiário:Ana Carolina Junqueira Vasques
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 08/09451-7 - Capacidade secretória de insulina em pacientes saudáveis, em obesos, em obesos diabéticos tipo 2 e em obesos diabéticos tipo 2 submetidos à cirurgia bariátrica através do clamp hiperglicêmico.
Beneficiário:Bruno Geloneze Neto
Linha de fomento: Auxílio à Pesquisa - Regular