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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Symptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorder

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Autor(es):
Kichuk, Stephen A. [1] ; Torres, Albina R. [2] ; Fontenelle, Leonardo F. [3] ; Rosario, Maria Conceicao [4] ; Shavitt, Roseli G. [5] ; Miguel, Euripedes C. [5] ; Pittenger, Christopher [1, 6, 7] ; Bloch, Michael H. [6, 7]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Yale Univ, Dept Psychiat, New Haven, CT 06520 - USA
[2] Univ Estadual Paulista, Botucatu Med Sch, Dept Neurol Psychol & Psychiat, Botucatu, SP - Brazil
[3] Univ Fed Rio de Janeiro, Inst Psychiat, Anxiety & Depress Res Program, Rio De Janeiro, RJ - Brazil
[4] Univ Fed Sao Paulo, Sch Med, Dept Psychiat, Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Sch Med, Dept Psychiat, Sao Paulo, SP - Brazil
[6] Yale Univ, Dept Psychol, New Haven, CT 06520 - USA
[7] Yale Univ, Ctr Child Study, New Haven, CT 06520 - USA
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; v. 44, p. 233-239, JUL 1 2013.
Citações Web of Science: 19
Resumo

Meta-analysis of the heterogeneous symptoms of obsessive-compulsive disorder (OCD) has found a four-factor structure of symptom dimensions consisting of cleaning, forbidden thoughts, symmetry, and hoarding. Research into age of onset of symptom dimensions has yielded inconsistent results, and it is unknown whether symptoms along these dimensions differ in their clinical course. We assessed age of onset and clinical course of different OCD symptom dimensions in a large cohort of adult patients. Nine-hundred fifty-five subjects were assessed using the Dimensional Yale-Brown Obsessive-Compulsive Scale. For age of onset analysis, we tested across three methods of classification: (1) primary (more severe) symptom dimension (2) clinically significant symptoms within a dimension or (3) any symptoms within a dimension. Age of onset was defined as the earliest age of onset reported for any individual item within a symptom dimension. For analysis of different types of clinical course, we used chi-square tests to assess for differences between primary symptom dimensions. OCD symptoms in the symmetry dimension had an earlier age of onset than other OCD symptom dimensions. These findings remained significant across all three methods of classification and controlling for gender and comorbid tics. No significant differences were found between the other dimensions. Subjects with primary OCD symptoms in the forbidden thoughts dimension were more likely to report a waxing-and-waning course, whereas symmetry symptoms were less likely to be associated with a waxing-and-waning course. (C) 2013 Published by Elsevier Inc. (AU)

Processo FAPESP: 05/55628-8 - Caracterização fenotípica, genética, imunológica e neurobiológica do transtorno obsessivo-compulsivo e suas implicações para o tratamento
Beneficiário:Eurípedes Constantino Miguel Filho
Linha de fomento: Auxílio à Pesquisa - Temático