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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Genome-wide association study for birth weight in Nellore cattle points to previously described orthologous genes affecting human and bovine height

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Autor(es):
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Utsunomiya, Yuri T. [1] ; do Carmo, Adriana S. [1] ; Carvalheiro, Roberto [2] ; Neves, Haroldo H. R. [1] ; Matos, Marcia C. [1] ; Zavarez, Ludmilla B. [1] ; O'Brien, Ana M. Perez [3] ; Soelkner, Johann [3] ; McEwan, John C. [4] ; Cole, John B. [5] ; Van Tassell, Curtis P. [6] ; Schenkel, Flavio S. [7] ; da Silva, Marcos V. G. B. [8] ; Porto Neto, Laercio R. [9, 10] ; Sonstegard, Tad S. [6] ; Garcia, Jose F. [11]
Número total de Autores: 16
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[1] UNESP, Univ Estadual Paulista, Fac Ciencias Agr Vet, BR-14884900 Jaboticabal, SP - Brazil
[2] GenSys Consultores Assoc, BR-90680000 Porto Alegre, RS - Brazil
[3] BOKU Univ Nat Resources & Life Sci, Dept Sustainable Agr Syst, Div Livestock Sci, Vienna - Austria
[4] Ctr Reprod & Genom, AgRes, Invermay, Mosgiel - New Zealand
[5] USDA ARS, Anim Improvement Programs Lab, Beltsville, MD 20705 - USA
[6] USDA, Agr Res Serv, Bovine Funct Genom Lab, Beltsville, MD 20705 - USA
[7] Univ Guelph, Ctr Genet Improvement Livestock, Guelph, ON N1G 2W1 - Canada
[8] Embrapa Dairy Cattle, Bioinformat & Anim Genom Lab, Juiz De Fora, MG - Brazil
[9] Univ Queensland, Sch Vet Sci, Gatton, Qld 4343 - Australia
[10] Univ New England, Sch Rural & Environm Sci, Armidale, NSW 2351 - Australia
[11] UNESP, Univ Estadual Paulista, Fac Med Vet Aracatuba, BR-16050680 Aracatuba, SP - Brazil
Número total de Afiliações: 11
Tipo de documento: Artigo Científico
Fonte: BMC GENETICS; v. 14, JUN 13 2013.
Citações Web of Science: 59
Resumo

Background: Birth weight (BW) is an economically important trait in beef cattle, and is associated with growthand stature-related traits and calving difficulty. One region of the cattle genome, located on Bos primigenius taurus chromosome 14 (BTA14), has been previously shown to be associated with stature by multiple independent studies, and contains orthologous genes affecting human height. A genome-wide association study (GWAS) for BW in Brazilian Nellore cattle (Bos primigenius indicus) was performed using estimated breeding values (EBVs) of 654 progeny-tested bulls genotyped for over 777,000 single nucleotide polymorphisms (SNPs). Results: The most significant SNP (rs133012258, P-GC = 1.34 x 10(-9)), located at BTA14: 25376827, explained 4.62% of the variance in BW EBVs. The surrounding 1 Mb region presented high identity with human, pig and mouse autosomes 8, 4 and 4, respectively, and contains the orthologous height genes PLAG1, CHCHD7, MOS, RPS20, LYN, RDHE2 (SDR16C5) and PENK. The region also overlapped 28 quantitative trait loci (QTLs) previously reported in literature by linkage mapping studies in cattle, including QTLs for birth weight, mature height, carcass weight, stature, pre-weaning average daily gain, calving ease, and gestation length. Conclusions: This study presents the first GWAS applying a high-density SNP panel to identify putative chromosome regions affecting birth weight in Nellore cattle. These results suggest that the QTLs on BTA14 associated with body size in taurine cattle (Bos primigenius taurus) also affect birth weight and size in zebu cattle (Bos primigenius indicus). (AU)

Processo FAPESP: 11/16643-2 - Estudo de associação genômica para a detecção de regiões cromossômicas relacionadas ao perímetro escrotal de bovinos Nelore
Beneficiário:Yuri Tani Utsunomiya
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 10/52030-2 - Estudos de associação genômica das características reprodutivas de touros zebuínos (Bos indicus) utilizando SNP chip de alta densidade
Beneficiário:José Fernando Garcia
Linha de fomento: Auxílio à Pesquisa - Regular