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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Susceptibility to Mycobacterium tuberculosis Infection in HIV-Positive Patients Is Associated With CARD8 Genetic Variant

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Autor(es):
Pontillo, Alessandra [1] ; Carvalho, Marcia S. [2] ; Kamada, Anselmo J. [2] ; Moura, Ronald [2] ; Schindler, Haiana C. [3] ; Duarte, Alberto J. S. [1] ; Crovella, Sergio [2]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med, Lab Med Invest Dermatol & Immunodeficiency, LIM 56, BR-05403000 Sao Paulo - Brazil
[2] Univ Fed Pernambuco, Dept Genet, Recife, PE - Brazil
[3] Aggeu Magalhaes Res Ctr CPqAM FIOCRUZ, Dept Immunol, Recife, PE - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES; v. 63, n. 2, p. 147-151, JUN 1 2013.
Citações Web of Science: 17
Resumo

HLA and other genetic variants, playing an important role in innate and adaptive immunity, are known to influence tuberculosis (TB) development in HIV-1-positive (HIV+) patients. Because inflammasome genes contribute to HIV-1 susceptibility, we investigated the possible association between polymorphisms in inflammasome genes with HIV-1 and Mycobacterium tuberculosis coinfection (HIV+ TB+) in a case/control cohort of Brazilian individuals. Nineteen single-nucleotide polymoprhims in 8 inflammasome genes (NLRP1, NLRP3, AIM2, CARD8, CASP1, IL1B, IL1R, and HSP90) were analyzed in HIV+ TB+ Brazilian patients (from Recife, Pernambuco). CARD8 rs6509365 polymorphism was associated with HIV+ TB+ (P = 5 x 10(-5)), suggesting a predisposing role of this variant in M. tuberculosis susceptibility in HIV+ subjects (odds ratio = 2.45). This effect is even strong when this allele is combined to CARD8 rs2043211 single-nucleotide polymoprhim. The results of this study support the novel association between CARD8 gene and HIV+ TB+ coinfection, demonstrating that inflammasome genetics could influence HIV-1 infection and the development of opportunistic infection. (AU)

Processo FAPESP: 09/53575-5 - Possível papel do inflamasoma na resposta imune ao vírus HIV-1
Beneficiário:Alberto José da Silva Duarte
Linha de fomento: Auxílio à Pesquisa - Regular