Simultaneous Voltammetric Determination of Acetaminophen and Caffeine at a Graphite and Polyurethane Screen-Printed Composite Electrode

Autor(es)

Saciloto, Thalita R. ^[1] ; Cervini, Priscila ^[1] ; Cavalheiro, Eder T. G. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Quim & Fis Mol, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 24, n. 9, p. 1461-1468, Set. 2013.
• Citações Web of Science: 16

Resumo

A selective electrochemical method was developed for the individual or simultaneous determination of acetaminophen and caffeine in phosphate buffer pH 6.0 on graphite and polyurethane screen-printed composite electrode (EIGPU) using Differential Pulse Voltammetry (DPV). The oxidation peaks of acetaminophen and the caffeine appeared at 0.3 V and 1.3 V(vs. pseudo-Ag/AgCl), respectively, showing the possibility of simultaneous determination of both analytes, at the EIGPU, besides the individual determination. Analytical curves for the simultaneous determination showed a linear response for both compounds. The acetaminophen presented a linear region in the concentration range 1.00 - 40.0 µmol L-1 with detection limit of 0.84 µmol L-1, and the caffeine presented a linear region, in the concentration range 4.00 - 200 µmol L-1 with detection limit of 1.6 µmol L-1. The proposed method was applied in the simultaneous determination of acetaminophen and caffeine in three pharmaceutical formulations, with results similar to those obtained using a HPLC method, at 95% confidence level (Student t-Test). (AU)

• Processo FAPESP: 10/11080-7 - Preparação e Aplicação de Eletrodos Compósitos à Base de Grafite e Polímeros: Modificação com Sílicas Organofuncionalizadas e Polímeros Molecularmente Impressos
• Beneficiário: Éder Tadeu Gomes Cavalheiro
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/05913-6 - Desenvolvimento e aplicação de eletrodos impressos descartáveis à base de compósitos grafite e poliuretana
• Beneficiário: Thalita Rocha Saciloto
• Linha de fomento: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 10/06485-8 - Desenvolvimento e aplicação de eletrodos compósitos impressos à base de grafite e PU e polímeros molecularmente impressos para fins analíticos
• Beneficiário: Priscila Cervini
• Linha de fomento: Auxílio à Pesquisa - Regular