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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Interleukin 4 haplotypes of susceptibility to chronic periodontitis are associated with IL-4 protein levels but not with clinical outcomes of periodontal therapy

Texto completo
Autor(es):
Anovazzi, Giovana [1, 2] ; Finoti, Livia S. [1, 2] ; Corbi, Samia C. T. [1, 2] ; Kim, Yeon J. [2] ; Marcaccini, Andrea M. [3] ; Gerlach, Raquel F. [3] ; Capela, Marisa V. [4] ; Orrico, Silvana R. P. [2] ; Cirelli, Joni A. [2] ; Scarel-Caminaga, Raquel M. [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] UNESP Sao Paulo State Univ, Sch Dent Araraquara, Dept Morphol, BR-14801903 Sao Paulo - Brazil
[2] UNESP Sao Paulo State Univ, Sch Dent Araraquara, Dept Oral Diag & Surg, BR-14801903 Sao Paulo - Brazil
[3] Univ Sao Paulo, Dent Sch Ribeirao Preto, Dept Morphol Stomatol & Physiol, BR-09500900 Sao Paulo - Brazil
[4] UNESP Sao Paulo State Univ, Inst Chem Araraquara, Dept Phys Chem, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: HUMAN IMMUNOLOGY; v. 74, n. 12, p. 1688-1695, DEC 2013.
Citações Web of Science: 8
Resumo

Different IL4 haplotypes were associated to susceptibility to/or protection against chronic periodontitis (CP). The aim of this study was to investigate if individuals carrying different haplotypes would present differences in clinical periodontal parameters and in the IL-4 levels at baseline, 45 and 90 days after nonsurgical periodontal therapy. 62 patients were subdivided: genetically protected without CP (PH), genetically protected with CF (PCP), genetically susceptible with CP (SCP), genetically susceptible without CF (healthy) (SH). Clinical examination and gingival crevicular fluid (GCF) collection were performed for all patients, and IL-4 levels were measured by ELISA. At baseline, higher values for plaque index (PI, p = 0.013), gingival index (GI, p = 0.005) were observed for the SCP group in comparison to the PCP group but not after the completion of periodontal therapy. 45 and 90 days after the non-surgical therapy, PCP demonstrated significantly higher IL-4 levels than the SCP (p = 0.000002). Correlation analysis showed different results between clinical parameters and IL-4 production or GCF volume for groups with different genetic loads. The IL4 gene which was previously associated with susceptibility to CP was related with differences in the IL-4 protein levels in the GCF. However, independent of genetic carriage, individuals responded similarly to this therapy. (C) 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 03/10424-0 - Investigação de polimorfismos no gene interleucina 8 e seus receptores em indivíduos com doença periodontal crônica
Beneficiário:Raquel Mantuaneli Scarel Caminaga
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/08773-3 - Análises clínica, microbiológica e imunológica em indivíduos com suscetibilidade genética à doença periodontal
Beneficiário:Raquel Mantuaneli Scarel Caminaga
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/11321-7 - Investigação do caráter multifatorial da doença periodontal: comparação de dados clínicos e imunológicos entre indivíduos suscetíveis geneticamente e não suscetíveis à periodontite
Beneficiário:Giovana Anovazzi Medeiros
Linha de fomento: Bolsas no Brasil - Mestrado