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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Does low birth weight affect the presence of cardiometabolic risk factors in overweight and obese children?

Texto completo
Autor(es):
Ponzio, Caroline [1] ; Palomino, Zaira [1] ; Puccini, Rosana Fiorini [2] ; Strufaldi, Maria Wany L. [2] ; Franco, Maria C. P. [1, 3]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Sch Med, Div Nephrol, BR-04023900 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Sch Med, Dept Pediat, BR-04023900 Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Med, Div Nephrol, BR-04023900 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: EUROPEAN JOURNAL OF PEDIATRICS; v. 172, n. 12, p. 1687-1692, DEC 2013.
Citações Web of Science: 3
Resumo

Recent findings suggest that low-birth-weight children with current obesity are more likely to have higher systolic blood pressure levels and impaired beta-cell function than those who are obese with normal birth weight. It seems possible, however, that concurrent low birth weight with excess weight gain can exacerbate other risk factors for cardiometabolic diseases. The purpose of this study is to investigate the influence of birth weight on the lipid/apolipoprotein profile, visfatin levels, and insulin parameters in overweight/obese children. A cross-sectional study of 68 overweight/obese children was conducted. Among these children, 28 were identified with low birth weight and 40 were of normal birth weight. Blood lipid profile, apolipoproteins, visfatin, glucose, and insulin were measured. Our results show that systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels, triglycerides (TG), very low-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDLc), apolipoprotein B and E, insulin, apolipoprotein B/A(1) ratio, and homeostasis model assessment insulin resistance (HOMA-IR) were significantly elevated in overweight/obese low-birth-weight (LBW) children. There was a significant association of the SBP levels with TG (P = 0.027), LDLc (P = 0.001), HOMA-IR (P < 0.001), apolipoprotein B (P = 0.001), and apolipoprotein E (P = 0.039). Conclusion: Our findings suggest that LBW children with overweight or obesity have an additional risk factor for both atherogenic and insulinogenic profile. (AU)

Processo FAPESP: 07/58044-2 - Peso ao nascer e doenças cardiovasculares: caracterização da inter-relação entre os fatores de risco e genéticos com a identificação dos mecanismos de imprinting genômico e dos polimorfismos genéticos da via da homocisteína e da eNOS
Beneficiário:Maria Do Carmo Pinho Franco
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores