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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Supercritical extraction of coumarin from guaco (Mikania laevigata and Mikania glomerata) for pharmaceutical applications

Texto completo
Autor(es):
Oliveira, A. L. [1] ; Pozza, L. N. L. [1] ; Santos, D. N. [1] ; Kamimura, E. S. [1] ; Vicente, E. [2] ; Cabral, F. A. [3]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, FZEA, Dept Engn Alimentos, BR-13635900 Pirassununga, SP - Brazil
[2] Inst Tecnol Alimentos ITAL, BR-13070178 Campinas, SP - Brazil
[3] Univ Estadual Campinas UNICAMP, Dept Engn Alimentos, BR-13083970 Campinas, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF SUPERCRITICAL FLUIDS; v. 83, p. 65-71, NOV 2013.
Citações Web of Science: 9
Resumo

Guaco has several applications in the chemical and pharmaceutical industries. This plant is a source of coumarin, a diterpene compound with expectorants properties. In Brazil, guaco extracts are used as medicinal products authorized by the National Health Surveillance Agency (ANVISA). Studies proved that guaco extracts are also effective against cancer, ulcers and infectious diseases. Supercritical extractions have been widely used to obtain highly pure natural extracts that do not contain organic solvents and have not lost their thermosensitive compounds and therefore are suitable for pharmaceutical applications. In this study, coumarin was obtained from guaco leaves extracts by supercritical extraction under different experimental conditions according to a central composite rotational design (CCRD) with two independent variables, temperature (T) and pressure (P). Lower values of T were used to maintain the stability of thermosensitive compounds and because coumarin is highly soluble in supercritical CO2 even at low T. The responses surface analyzes (RSA) acquired by fitting of linear and quadratic models to experimental extraction yields and coumarin concentrations showed similar conditions for improving yields from both plant species. Although the extract yield values were similar for both plant species, coumarin concentrations were higher in Mikania laevigata than Mikania glomerata. The greater extract yield of 4.20% coumarin, related to the higher coumarin concentration (0.43 g x 100 g(-1) in guaco leaves), was obtained under extraction conditions of P above 175 bar and T above 45 degrees C. (C) 2013 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 06/00042-1 - Estudo da concentração de cumarina nos extratos de guaco (Mikania laevigata ou Mikania glomerata) obtidos pelo emprego de CO2 supercrítico
Beneficiário:Letícia Nasser Lauandos Pozza
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 05/02538-1 - Aplicação do método de volumes finitos e de modelos Lattice-Boltzmann para a simulação de processos e equipamentos de interesse à indústria de alimentos
Beneficiário:Jose Antonio Rabi
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 04/07011-9 - Emprego de tecnologia "clean" (extração com dióxido de carbono supercrítico) na obtenção da fração aromática e dos princípios ativos de frutos tropicais brasileiros
Beneficiário:Alessandra Lopes de Oliveira
Linha de fomento: Auxílio à Pesquisa - Regular