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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Spontaneously Hypertensive Rats: Possible Animal Model of Sleep-Related Movement Disorders

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Autor(es):
Esteves, Andrea M. [1] ; Lopes, Cleide [2] ; Frussa-Filho, Roberto [3] ; Frank, Miriam K. [1] ; Cavagnolli, Daniel [2] ; Arida, Ricardo M. [4] ; Tufik, Sergio [2] ; de Mello, Marco Tulio [2]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Fac Ciencias Aplicadas, Limeira, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Farmacol, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Dept Fisiol, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF MOTOR BEHAVIOR; v. 45, n. 6, p. 487-493, NOV 1 2013.
Citações Web of Science: 5
Resumo

Clinical experience suggests that restless legs syndrome (RLS), periodic leg movement (PLM), and attention-deficit hyperactivity disorder (ADHD) may co-occur in both children and adults. The purpose of the present study was to provide an electrocorticography and electromyography evaluation of the spontaneously hypertensive rat (SHR) to investigate the potential of this rat strain as an animal model of RLS-PLM. Initial work focused on evaluating sleep patterns and limb movements during sleep in SHR, having normotensive Wistar rats (NWR) as control, followed by comparison of two treatments (pharmacological-dopaminergic agonist treatment and nonpharmacological-chronic physical exercise), known to be clinically beneficial for sleep-related movement disorders. The captured data strengthen the association between SHR and RLS-PLM, revealing a significant reduction on sleep efficiency and slow wave sleep and an increase on wakefulness and limb movements for the SHR group during the dark period, as compared to the NWR group, effects that have characteristics that are strikingly consistent with RLS-PLM. The pharmacological and nonpharmacological manipulations validated these results. The present findings suggest that the SHR may be a useful putative animal model to study sleep-related movement disorders mechanisms. (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 08/50646-6 - Efeitos do exercício físico em um modelo animal de síndrome das pernas inquietas e de movimentos periódicos das pernas
Beneficiário:Andrea Maculano Esteves
Linha de fomento: Bolsas no Brasil - Pós-Doutorado