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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Differential pulse adsorptive stripping voltammetric determination of methotrexate using a functionalized carbon nanotubes-modified glassy carbon electrode

Texto completo
Autor(es):
Oliveira, Geiser G. [1] ; Janegitz, Bruno C. [2] ; Zucolotto, Valtencir [2] ; Fatibello-Filho, Orlando [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Fed Sao Carlos, Dept Chem, Ctr Sci & Technol, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Nanomed & Nanotoxicol Grp, Sao Carlos Inst Phys, BR-13566590 Sao Carlos, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: CENTRAL EUROPEAN JOURNAL OF CHEMISTRY; v. 11, n. 11, p. 1837-1843, NOV 2013.
Citações Web of Science: 13
Resumo

A glassy carbon electrode (GC) containing multiwalled functionalized carbon nanotubes (MWCNTs) immobilized within a dihexadecylhydrogenphosphate film (DHP) is proposed as a nanostructured platform for determination of methotrexate (MTX) concentration (a drug used in cancer treatment) using differential pulse adsorptive stripping voltammetry (DPAdSV). The voltammograms for a MTX solution using MWCNTs-DHP/GC electrode presented an oxidation peak potential at 0.98 V vs. Ag/AgCl (3.0 mol L-1 KCl) in a 0.1 mol L-1 sulphuric acid. The apparent heterogeneous electron transfer rate constant of 0.46 s(-1) was calculated. The recovery area of 2.62 x 10(-9) mol cm(2) was also obtained. Under the optimal experimental conditions, the analytical curve was linear in the MTX concentration range from 5.0 x 10(-8) to 5.0 x 10(-6) mol L-1, with a detection limit of 3.3 x 10(-8) mol L-1. The MWCNTs-DHP/GC electrode can be easily prepared and was applied for the determination of MTX in pharmaceutical formulations, with results similar to those obtained using a high-performance liquid chromatography comparative method. (AU)

Processo FAPESP: 12/02877-4 - Desenvolvimento de novos biossensores utilizando materiais nanoestruturados ativos
Beneficiário:Bruno Campos Janegitz
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 08/09893-0 - Desenvolvimento de biossensores utilizando nanotubos de carbono e nanopartículas
Beneficiário:Bruno Campos Janegitz
Linha de fomento: Bolsas no Brasil - Doutorado