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Association between IL8 haplotypes and pathogen levels in chronic periodontitis

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Autor(es):
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Finoti, L. S. [1] ; Corbi, S. C. T. [1] ; Anovazzi, G. [1] ; Teixeira, S. R. L. [2] ; Steffens, J. P. [3] ; Secolin, R. [4] ; Kim, Y. J. [5] ; Orrico, S. R. P. [1] ; Cirelli, J. A. [1] ; Mayer, M. P. A. [2] ; Scarel-Caminaga, R. M. [6]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista, UNESP, Sch Dent Araraquara, Dept Oral Diag & Surg, BR-14801903 Araraquara, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo - Brazil
[3] Univ Estadual Paulista, UNESP, Sch Dent Araraquara, Dept Physiol & Pathol, BR-14801903 Araraquara, SP - Brazil
[4] Univ Campinas UNICAMP, Dept Med Genet, Campinas, SP - Brazil
[5] Univ Santo Amaro, Dept Implantol, Sao Paulo - Brazil
[6] Univ Estadual Paulista, UNESP, Sch Dent Araraquara, Dept Morphol, BR-14801903 Araraquara, SP - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES; v. 32, n. 10, p. 1333-1340, OCT 2013.
Citações Web of Science: 8
Resumo

Chronic periodontitis (CP) is considered to be a multifactorial disease influenced by microbial and genetic factors. The aim of the present study was to investigate whether the genetic susceptibility to CP in individuals with the IL8 ATC/TTC haplotype is associated with subgingival levels of periodontopathogens. Sixty-five individuals, grouped according to the presence (n = 28) or absence (n = 37) of the IL8 haplotype, were evaluated. After clinical periodontal evaluation, each group was subdivided according to the presence (CP) or absence (H) of periodontitis. Four subgingival samples were obtained from CP and two samples per subject from H patients. The levels and proportions of Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola were analyzed using quantitative real-time polymerase chain reaction (q-PCR). No differences were found in the proportion of periodontopathogenic bacteria between groups with the presence or absence of the IL8 haplotype. However, in the CP groups, the levels of periodontopathogens were significantly higher in the individuals without the IL8 haplotype than in the individuals with the IL8 haplotype. These results suggest that periodontal destruction may occur in patients who are considered to be genetically susceptible to CP with a lower microbial challenge because of the presence of the IL8 ATC/TTC haplotype than in patients without this haplotype. (AU)

Processo FAPESP: 03/10424-0 - Investigação de polimorfismos no gene interleucina 8 e seus receptores em indivíduos com doença periodontal crônica
Beneficiário:Raquel Mantuaneli Scarel Caminaga
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/11371-4 - Investigação comparativa de dados clínicos e microbiológicos entre indivíduos suscetíveis geneticamente e não susceptíveis à periodontite
Beneficiário:Livia Sertori Finoti
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 09/08773-3 - Análises clínica, microbiológica e imunológica em indivíduos com suscetibilidade genética à doença periodontal
Beneficiário:Raquel Mantuaneli Scarel Caminaga
Linha de fomento: Auxílio à Pesquisa - Regular