Chloroquine: Modes of action of an undervalued drug

Autor(es)

Thome, Rodolfo ^[1] ; Pinto Lopes, Stefanie Costa ^[2] ; Maranhao Costa, Fabio Trindade ^[2] ; Verinaud, Liana ^[1]

Afiliação do(s) autor(es)

^[1] Univ Campinas Unicamp, Inst Biol, Dept Struct & Funct Biol, Sao Paulo - Brazil

^[2] Univ Campinas UNICAMP, Inst Biol, Dept Genet Evolut & Bioagents, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Immunology Letters; v. 153, n. 1-2, p. 50-57, JUN 2013.
• Citações Web of Science: 56

Resumo

For more than two decades, chloroquine (CQ) was largely and deliberately used as first choice drug for malaria treatment. However, worldwide increasing cases of resistant strains of Plasmodium have hampered its use. Nevertheless, CQ has recently been tested as adjunct therapy in several inflammatory situations, such as rheumatoid arthritis and transplantation procedures, presenting intriguing and promising results. In this review, we discuss recent findings and CQ mechanisms of action vis-a-vis its use as a broad adjunct therapy. (C) 2013 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 11/17965-3 - Efeito da atrofia tímica induzida pela infecção com Plasmodium berghei no estabelecimento e curso da encefalomielite autoimune experimental (EAE)
• Beneficiário: Liana Maria Cardoso Verinaud
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/13191-3 - Efeito da atrofia tímica induzida pela infecção com Plasmodium berghei sobre a indução e desenvolvimento da EAE experimental
• Beneficiário: Rodolfo Thomé
• Modalidade de apoio: Bolsas no Brasil - Doutorado