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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effects of ozone applied by spinal endoscopy in patients with chronic pain related to failed back surgery syndrome: a pilot study

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Autor(es):
de Oliveira Magalhaes, Francisco Neuton [1] ; Soares, Sandra Correia [1] ; Torres, Jaqueline Melo [1] ; Ungaretti, Arthur [1] ; Cacciacarro, Mariana Fillipi [1] ; Teixeira, Manoel Jacobsen [1] ; Fonoff, Erich Talamoni [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med, Div Funct Neurosurg, Dept Neurol, BR-01060970 Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: NEUROPSYCHIATRIC DISEASE AND TREATMENT; v. 9, p. 1759-1766, 2013.
Citações Web of Science: 11
Resumo

Introduction: In the last two decades, ozone has emerged as a treatment for low back pain, applied by means of minimally invasive techniques. Objective: The aim of this study is to assess the effect and safety of ozone therapy applied in the epidural space for chronic pain related to failed back surgery syndrome. Methods: The investigators studied 13 sequential patients of both sexes, between 18 and 70 years old, with persistent chronic pain (more than six months) in the lumbar region and in the lower limbs related to failed back surgery syndrome (FBSS). Pain was classified as neuropathic and non-neuropathic regarding the topography (lumbar and lower limb), based on the DN4 (Douleur Neuropathique 4) questionnaire. The patients received the ozone gas in the lumbar epidural space via spinal-sacral endoscopy. Clinical evaluation was performed before, immediately after (24 hours), and 1, 3, and 6 months after intervention with visual analog scale and Oswestry Disability Index (ODI). Results: Overall, the patients had 43.7% reduction of lumbar pain, 60.9% reduction in leg pain in six months followed by 44.0% of improvement in ODI. The reduction of pain and in the disability index was markedly greater in patients with non-neuropathic predominant pain, 95.2%, 80.6%, and 75.3% improvement in lumbar, leg pain, and ODI respectively, while neuropathic predominant pain patients experienced only 12.5%, 42.4%, and 20.9% improvement, also respectively. No neurological or infectious complications were observed acutely or during the follow-up. The present data suggests that epidural ozone might be a therapeutic option for persistent low back pain, especially in non-neuropathic predominant pain patients, but double-blind controlled studies are still required to prove its efficacy. (AU)

Processo FAPESP: 11/08529-5 - Estudo controlado e duplamente encoberto sobre o efeito do ozônio aplicado por endoscopia espinhal no tratamento da síndrome dolorosa pós-laminectomia: análise na dor neuropática e não neuropática e sua correlação com o nível de citocinas epidurais
Beneficiário:Erich Talamoni Fonoff
Linha de fomento: Auxílio à Pesquisa - Regular