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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Higher Incidence of Lung Adenocarcinomas Induced by DMBA in Connexin 43 Heterozygous Knockout Mice

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Autor(es):
de Oliveira, Krishna Duro [1] ; Tedardi, Marcello Vannucci [1] ; Cogliati, Bruno [1] ; Zaidan Dagli, Maria Lucia [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, BR-05508900 Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: BIOMED RESEARCH INTERNATIONAL; 2013.
Citações Web of Science: 11
Resumo

Gap junctions are communicating junctions which are important for tissue homeostasis, and their disruption is involved in carcinogenic processes. This study aimed to verify the influence of deletion of one allele of the Connexin 43 gene on cancer incidence in different organs. The 7,12-dimethylbenzanthracene (DMBA) carcinogenic model, using hebdomadary doses by gavage of 9 mg per animal, was used to induce tumors in Connexin 43 heterozygous or wild-type mice. The experiment began in the eighth week of the mice life, and all of them were euthanized when reaching inadequate physical condition, or at the end of 53 weeks. No statistical differences occurred for weight gain and cancer survival time (P = 0.9853) between heterozygous and wild-type mice. Cx43(+/-) mice presented significantly higher susceptibility to lung cancer (P = 0.0200) which was not evidenced for benign neoplasms (P = 0.3449). In addition, incidence of ovarian neoplasms was 2.5-fold higher in Cx43(+/-) mice, although not statistically significant. Other organs showed a very similar cancer occurrence between Cx43 groups. The experiment strengthens the evidence of the relationship between Connexin 43 deficiency and carcinogenesis. (AU)

Processo FAPESP: 10/00874-2 - Avaliação da expressão de receptores de estrógeno e progesterona, E-caderina, citoqueratinas 5 e 14, vimentina, c-kit, PCNA e PTEN em neoplasias mamárias induzidas em camundongos Balb/c por 7,12-dimetilbenzantraceno (DMBA)
Beneficiário:Marcello Vannucci Tedardi
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 10/08480-3 - Carcinogênese mamária induzida por DMBA em camundongos geneticamente modificados, deficientes em conexina 43
Beneficiário:Maria Lucia Zaidan Dagli
Linha de fomento: Auxílio à Pesquisa - Regular