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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease

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Autor(es):
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Gregorio, Michele L. [1] ; Pinhel, Marcela A. S. [1, 2] ; Sado, Caroline L. [3] ; Longo, Gabriela S. [4] ; Oliveira, Fabio N. [4] ; Amorim, Gisele S. [5] ; Nakazone, Marcelo A. [1] ; Florim, Greiciane M. [5] ; Mazeti, Camila M. [5] ; Martins, Denise P. [5] ; Tognola, Waldir A. [6] ; Brandao, Antonio C. [6] ; Pinheiro Junior, Sidney [1] ; de Godoy, Moacir F. [4] ; Souza, Doroteia R. S. [3]
Número total de Autores: 15
Afiliação do(s) autor(es):
[1] Sao Jose do Rio Preto Med Sch FAMERP, Dept Mol Biol, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[2] NPBIM, Ctr Res Biochem & Mol Biol, Sao Jose do Rio Preto Med Sch FAMERP, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[3] Fed Univ Sao Paulo UNIFESP, BR-04021001 Sao Paulo - Brazil
[4] Hosp Base, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[5] Sao Jose do Rio Preto Med Sch FAMERP, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[6] Sao Jose do Rio Preto Med Sch FAMERP, Dept Neurosci Mol Biol, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: BIOMED RESEARCH INTERNATIONAL; 2013.
Citações Web of Science: 10
Resumo

The pathogenesis of Parkinson's disease (PD) seems to involve genetic susceptibility to neurodegeneration. APOE gene has been considered a risk factor for PD. This study aimed to evaluate the association of APOE polymorphism with PD and its influence on lipid profile. We studied 232 PD patients (PD) and 169 individuals without the disease. The studied polymorphism was analyzed by PCR/RFLP. The Fisher's exact test, chi-square, ANOVA, and t-test (P < 0.05) were applied. The APOE3/3 genotype was prevalent in PD patients and Controls (P = 0.713) followed by APOE3/4 (P = 0.772). Both groups showed recommended values for lipid profile, with increase in the values of total cholesterol and LDLc, as well as decreased values of triglycerides in PD patients compared with Controls (P < 0.05 for all of them). Increased levels of HDLc, in PD patients, were associated with the APOE3/3 versus APOE-/4 genotypes (P = 0.012). The APOE polymorphism does not distinguish PD patients from Controls, as opposed to the lipid profile alone or in association with APOE. Furthermore, a relationship between increase of HDLc levels and APOE3 in homozygous was found in PD patients only. (AU)

Processo FAPESP: 09/18476-6 - Impacto das Variantes Genéticas da Apolipoproteína E no Perfil Lipídico em Pacientes com Doença de Parkinson
Beneficiário:Caroline Leiko Sado
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 09/17222-0 - Impacto da variante GSTP1 Alw 26I como enzima detoxificante de xenobióticos na Doença de Parkinson
Beneficiário:Gabriela dos Santos Longo
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 08/53950-8 - Relevancia das variantes geneticas de lrrk2 e glutationa s-transferases para doenca de parkinson
Beneficiário:Waldir Antonio Tognola
Linha de fomento: Auxílio à Pesquisa - Regular