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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Diagnosis and classification of autoimmune orchitis

Texto completo
Autor(es):
Silva, C. A. [1, 2] ; Cocuzza, M. [3, 4] ; Carvalho, J. F. [5] ; Bonfa, E. [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Div Rheumatol, Fac Med, BR-01246903 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Pediat, Fac Med, Pediat Rheumatol Unit, BR-01246903 Sao Paulo - Brazil
[3] Univ Sao Paulo, Human Reprod Ctr, Fac Med, BR-01246903 Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Androl, Fac Med, BR-01246903 Sao Paulo - Brazil
[5] Univ Fed Bahia, Div Rheumatol, BR-41170290 Salvador, BA - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo de Revisão
Fonte: AUTOIMMUNITY REVIEWS; v. 13, n. 4-5, SI, p. 431-434, APR-MAY 2014.
Citações Web of Science: 20
Resumo

Autoimmune orchitis is characterized by testis inflammation and the presence of specific antisperm antibodies (ASA). It is classified in two categories. Primary autoimmune orchitis is defined by infertility and asymptomatic orchitis associated with ASA (100%) directed to the basement membrane or seminiferous tubules in infertile men, without any systemic disease and usually asymptomatic. Secondary autoimmune orchitis is characterized by symptomatic orchitis and/or testicular vasculiti's associated with a systemic autoimmune disease, particularly vasculitis. These patients typically demonstrate testicular pain, erythema and/or swelling. ASA in secondary autoimmune orchitis have been reported in up to 50% of patients, especially in systemic lupus erythematosus patients. The pathogenesis of primary as well as secondary autoimmune orchitis is still unknown. Although the etiology is likely to be multifactorial, testicular inflammation, infection or trauma may induce T cell response with pro-inflammatory cytokine production with a consequent blood-testis-barrier permeability alteration, ASA production and apoptosis of spermatocytes and spermatids. ASA is known to cause immobilization and/or agglutination of spermatozoa, which may block sperm-egg interaction resulting in infertility. Assisted reproduction has been used as an efficient option in primary cases and immunosuppressive therapy for secondary autoimmune orchitis, although there is no double-blind, randomized trial to confirm the efficacy of any treatment regimens for these conditions. (C) 2014 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 09/51897-5 - Terapia anti-TNF em doenças auto-imunes reumatológicas: abordagem de aspectos peculiares
Beneficiário:Eloisa Silva Dutra de Oliveira Bonfá
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 11/12471-2 - Avaliação da reserva ovariana, do anticorpo anti-corpo lúteo e da infecção do trato genital inferior de mulheres adultas com lúpus eritematoso sistêmico, síndrome de Behçet e arterite de Takayasu
Beneficiário:Clovis Artur Almeida da Silva
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/58238-4 - Autoimunidade na criança: investigação das bases moleculares e celulares da autoimunidade de início precoce
Beneficiário:Magda Maria Sales Carneiro-Sampaio
Linha de fomento: Auxílio à Pesquisa - Temático