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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

What is the best treatment to decrease pro-inflammatory cytokine release in acute skeletal muscle injury induced by trauma in rats: low-level laser therapy, diclofenac, or cryotherapy?

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de Almeida, Patricia [1] ; Tomazoni, Shaiane Silva [2] ; Frigo, Lucio [3] ; Camillo de Carvalho, Paulo de Tarso [1, 4] ; Vanin, Adriane Aver [1] ; Santos, Larissa Aline [1] ; Albuquerque-Pontes, Gianna Moes [4] ; De Marchi, Thiago [5] ; Tairova, Olga [5] ; Marcos, Rodrigo Labat [4] ; Brandao Lopes-Martins, Rodrigo Alvaro [4, 2] ; Pinto Leal-Junior, Ernesto Cesar [1, 4]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Univ Nove Julho UNINOVE, Postgrad Program Rehabil Sci, BR-01504001 Sao Paulo - Brazil
[2] Univ Sao Paulo, Lab Pharmacol & Expt Therapeut, Dept Pharmacol, Inst Biomed Sci, Sao Paulo - Brazil
[3] Univ Cruzeiro Sul, Biol Sci & Hlth Ctr, Sao Paulo - Brazil
[4] Univ Nove Julho UNINOVE, Postgrad Program Biophoton Appl Hlth Sci, BR-01504001 Sao Paulo - Brazil
[5] Univ Caxias Sul UCS, Sports Med Inst, Caxias do Sul, RS - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Lasers in Medical Science; v. 29, n. 2, SI, p. 653-658, MAR 2014.
Citações Web of Science: 30

Currently, treatment of muscle injuries represents a challenge in clinical practice. In acute phase, the most employed therapies are cryotherapy and nonsteroidal anti-inflammatory drugs. In the last years, low-level laser therapy (LLLT) has becoming a promising therapeutic agent; however, its effects are not fully known. The aim of this study was to analyze the effects of sodium diclofenac (topical application), cryotherapy, and LLLT on pro-inflammatory cytokine levels after a controlled model of muscle injury. For such, we performed a single trauma in tibialis anterior muscle of rats. After 1 h, animals were treated with sodium diclofenac (11.6 mg/g of solution), cryotherapy (20 min), or LLLT (904 nm; superpulsed; 700 Hz; 60 mW mean output power; 1.67 W/cm(2); 1, 3, 6 or 9 J; 17, 50, 100 or 150 s). Assessment of interleukin-1 beta and interleukin-6 (IL-1 beta and IL-6) and tumor necrosis factor-alpha (TNF-alpha) levels was performed at 6 h after trauma employing enzyme-linked immunosorbent assay method. LLLT with 1 J dose significantly decreased (p < 0.05) IL-1 beta, IL-6, and TNF-alpha levels compared to non-treated injured group as well as diclofenac and cryotherapy groups. On the other hand, treatment with diclofenac and cryotherapy does not decrease pro-inflammatory cytokine levels compared to the non-treated injured group. Therefore, we can conclude that 904 nm LLLT with 1 J dose has better effects than topical application of diclofenac or cryotherapy in acute inflammatory phase after muscle trauma. (AU)

Processo FAPESP: 10/52404-0 - Laserterapia de baixa potência na fadiga muscular e recuperação muscular pós-exercício: parâmetros ideais de aplicação e efeitos em exercício de longa duração
Beneficiário:Ernesto Cesar Pinto Leal Junior
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
Processo FAPESP: 12/06832-5 - Laserterapia de baixa potência e diclofenaco sódico de uso tópico na lesão muscular induzida por contusão em ratos
Beneficiário:Lúcio Frigo
Linha de fomento: Auxílio à Pesquisa - Regular