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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Oxidative stress and fatty acid profile in Wistar rats subjected to acute food restriction and refeeding with high-fat diets

Autor(es):
da Silva Nassar, Ana Ligia [1] ; Marot, Luisa Pereira [1] ; Ovidio, Paula Payao [2] ; Ferreira de Castro, Gabriela Salim [3] ; Jordao Junior, Alceu Afonso [4]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Internal Med, BR-14049 Ribeirao Preto, SP - Brazil
[2] FMRP USP, Dept Internal Med, Lab Nutr & Metab, Ribeirao Preto, SP - Brazil
[3] FMRP USP, Dept Internal Med, Postgrad Program Internal Med, Ribeirao Preto, SP - Brazil
[4] FMRP USP, Dept Internal Med, Ribeirao Preto, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Acta Cirurgica Brasileira; v. 29, n. 3, p. 178-185, MAR 2014.
Citações Web of Science: 3
Resumo

PURPOSE: To assess oxidative stress and the profile of fatty acids incorporated into the hepatic tissue of animals refed with high-fat (HF) diets after acute food restriction. METHODS: Fifty male Wistar rats were divided into five groups and fasting for 48 hours. One group was sacrificed without refeeding (NR), a control group (C) was refed with the standard AIN-93 diet and the remaining groups with HF diets respectively consisting of hydrogenated vegetable oil (PHVO), trans-free (TF) margarine and trans-free margarine enriched with omega-3 and omega-6 (O). After this period the animals were sacrificed for malondialdehyde (MDA), catalase and hepatic fatty acid determination. RESULTS: The groups refed with HF diets showed elevation of MDA levels compared to the C group (p<0.001 for GVH and p<0.01 for TF and O). Hepatic catalase activity was higher in the TF and O groups compared to group C (p<0.05 for both). The amount of saturated fatty acids was lower in the PHVO and O groups compared to the remaining ones (p<0.001). CONCLUSION: The consumption of high-fat diets after prolonged fasting favors oxidative imbalance in hepatic tissue. (AU)

Processo FAPESP: 10/00408-1 - Efeitos dos ácidos graxos n-3 provenientes do óleo de peixe no metabolismo lipídico e expressão gênica de ratos alimentados com dieta rica em frutose
Beneficiário:Gabriela Salim Ferreira de Castro
Linha de fomento: Bolsas no Brasil - Doutorado