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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Phytoremediation Potential of Mana-Cubiu (Solanum sessiliflorum Dunal) for the Deleterious Effects of Methylmercury on the Reproductive System of Rats

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Autor(es):
da Silva, Raquel Frenedoso [1] ; Missassi, Gabriela [1] ; Borges, Cibele dos Santos [1] ; de Paula, Eloisa Silva [2] ; Hornos Carneiro, Maria Fernanda [2] ; Grotto, Denise [2] ; Barbosa Junior, Fernando [2] ; Kempinas, Andwilma De Grava [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista UNESP, Dept Morphol, Inst Biosci, BR-18618970 Botucatu, SP - Brazil
[2] Univ Sao Paulo, Dept Clin Anal Toxicol & Food Sci, Sch Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: BIOMED RESEARCH INTERNATIONAL; 2014.
Citações Web of Science: 1
Resumo

Methylmercury, organic form of mercury, can increase the number of abnormal sperm and decrease sperm concentration and testosterone levels possibly due to the damage caused by reactive species to germ and Leydig cells. Mana-cubiu (Solanum sessiliflorum Dunal) is a native fruit from Amazon rich in iron, zinc, niacin, pectin, and citric acid, used in foods, beverages, and medicinal purposes, since it has been useful for treatment of various diseases caused by oxidative stress or nutritional deficiency. Therefore, this study evaluated the phytoremediation potential of this fruit on damages caused by exposure to MeHg on sperm quantity and quality and the histological aspect of the testis and epididymis. Wistar male rats (n = 20) were randomly allocated into four groups: Control group (received distilled water), MeHg group (140 mu g/Kg), Solanum group (1% of fruit Mana-cubiu on chow), and Solanum plus MeHg group (same treatment as MeHg and Solanum group). The organs were weighted, histopathology; sperm morphology and counts were obtained. The results showed reduction in body weight gain, testis weights, reduced sperm production, and increased histopathological abnormalities in the MeHg-treated group. However, treatment with Solanum plus MeHg revealed a protective effect of this fruit on damages caused by MeHg. (AU)

Processo FAPESP: 13/05560-4 - Coexposição a metilmercúrio e chumbo em ratos: distribuição no organismo, avaliação da genotoxicidade e parâmetros de estresse oxidativo, e possível efeito protetor do fruto maná cubiu (Solanum sessiliflorum Dunal)
Beneficiário:Eloisa Silva de Paula
Linha de fomento: Bolsas no Brasil - Doutorado