Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats

Autor(es)

Brandt, Joyce Zalotti ^[1] ; Silveira, Livia Teresa R. ^[1] ; Grassi, Tony Fernando ^[2] ; Anselmo-Franci, Janete A. ^[3] ; Favaro, Wagner Jose ^[4] ; Felisbino, Sergio Luis ^[1] ; Barbisan, Luis Fernando ^[1] ; Scarano, Wellerson Rodrigo ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, Inst Biosci, Dept Morphol, UNESP, BR-18618970 Botucatu, SP - Brazil

^[2] UNESP, Sch Med, Dept Pathol, BR-18618970 Botucatu, SP - Brazil

^[3] Univ Sao Paulo FORP USP, Fac Dent, BR-14040904 Ribeirao Preto, SP - Brazil

^[4] Univ Estadual Campinas, UNICAMP, Inst Biol, BR-13083862 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: REPRODUCTIVE TOXICOLOGY; v. 43, p. 56-66, JAN 2014.
• Citações Web of Science: 17

Resumo

Bisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated with 25 or 250 mu g/kg BPA from gestational day (GD) 10 to GD21 with or without concurrent indole-3-carbinol (I3C) feeding. I3C is a phytochemical, and it affords chemoprotection against many types of neoplasia. Male F1 rats from different litters were euthanized on post-natal day (PND) 21 and PND180. BPA-treated groups showed a significant increase in histopathological lesions, but I3C feeding reversed many of these changes, mainly at PND180. Maternal I3C feeding increased prostate epithelial apoptosis in the BPA-treated groups and across age groups. Furthermore, I3C induced partial normalization of the prostate histoarchitecture. The results pointed to a protective effect of maternal I3C feeding during pregnancy in the BPA-exposed male offspring, thereby indicating reduction in the harmful effects of gestational BPA imprinting on the prostate. (C) 2013 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 10/17262-0 - Exposição in utero e lactacional ao desregulador endócrino bisfenol A e ao agente quimiopreventivo Indol-3-Carbinol: efeitos na morfogênese inicial da próstata e na susceptibilidade à carcinogênese prostática em ratos Sprague-Dawley
• Beneficiário: Joyce Zalotti Brandt
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 10/14110-4 - Exposição in útero ao desregulador endócrino Bisfenol A e a agentes quimiopreventivos na susceptibilidade a carcinogênese mamária em ratas Sprague-Dawley.
• Beneficiário: Luís Fernando Barbisan
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/01954-2 - Exposição in útero ao Bisfenol A (BPA) e ao agente quimiopreventivo Indol-3-Carbinol (I3C): efeitos imediatos e tardios sobre a morfologia e os processos de proliferação e morte celular na próstata de ratos.
• Beneficiário: Lívia Teresa Ribeiro da Silveira
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica