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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Grape juice concentrate protects reproductive parameters of male rats against cadmium-induced damage: a chronic assay

Texto completo
Autor(es):
Pires, Vanessa Cardoso [1] ; Boiago Golluecke, Andrea Pittelli [2, 3] ; Ribeiro, Daniel Araki [1] ; Lungato, Lisandro [4] ; D'Almeida, Vania [4] ; Aguiar, Jr., Odair [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo UNIFESP, Dept Biociencias, BR-11060001 Santos, SP - Brazil
[2] Univ Catolica Santos, Hexalab, Santos, SP - Brazil
[3] Univ Catolica Santos, Dept Nutr, Santos, SP - Brazil
[4] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: BRITISH JOURNAL OF NUTRITION; v. 110, n. 11, p. 2020-2029, DEC 14 2013.
Citações Web of Science: 14
Resumo

The aim of the present study was to investigate the effects of long-term grape juice concentrate (GJC) consumption, in two dosages, on the reproductive parameters of cadmium-exposed male rats. The effects of the concentrate on body mass gain, plasma testosterone levels, reproductive organ weights, daily sperm production, sperm morphology, testis histopathological and histomorphometrical parameters, and testicular antioxidant markers were investigated. Wistar rats (n 54) were distributed into six groups: CdCl2; cadmium and grape juice I (1.18 g/kg per d); cadmium and grape juice II (2.36 g/kg per d); grape juice I (1.18 g/kg per d); grape juice II (2.36 g/kg per d); control. A single dose of CdCl2 (1.2 mg/kg body weight (BW)) was injected intraperitoneally and the grape juice was administered orally for 56 d. The results indicated that cadmium changed all reproductive and antioxidant parameters. At dosage I (1.18 g/kg BW), GJC consumption did not show the effects against cadmium-induced damages. In contrast, at dosage II (2.36 g/kg BW), the GJC improved the gonadosomatic index (P=0.003), serum testosterone levels (P=0.001), the relative weight of epididymis (P=0.013) and ventral prostate (P=0.052), the percentage of normal sperm (P=0.001), and histopathological and histomorphometrical parameters. In addition, at this dosage, normalisation of the enzymatic activity of superoxide dismutase (P=0.001) and of testicular levels of glutathione (P=0.03) were observed. The parameters of the non-exposed rats did not depict significant alterations. In conclusion, the product was able to act as a protector of reproductive function against cadmium-induced damage. Such a property was expressed in a dose-dependent manner as the more effective dose was dosage II. The GJC acted possibly by antioxidant mechanisms. (AU)

Processo FAPESP: 11/03873-0 - Efeitos do concentrado de suco de uva, rico em resveratrol e outros polifenóis, em parâmetros reprodutivos de ratos expostos ao cloreto de cádmio
Beneficiário:Vanessa Cardoso Pires
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 11/22811-5 - Investigação dos efeitos do concentrado de suco de uva e do extrato de castanha do Brasil (Bertholletia excelsa) sobre os danos induzidos pelo cádmio na espermatogênese e outros parâmetros reprodutivos de ratos wistar
Beneficiário:Odair Aguiar Junior
Linha de fomento: Auxílio à Pesquisa - Regular