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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

MSX1 gene polymorphisms in non-syndromic cleft lip and/or palate

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Autor(es):
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Cardoso, M. L. [1] ; Bezerra, J. F. [1] ; Oliveira, G. H. M. [1] ; Soares, C. D. [1] ; Oliveira, S. R. [2] ; de Souza, K. S. C. [1] ; da Silva, H. P. V. [1] ; Silbiger, V. N. [1] ; Luchessi, A. D. [3] ; Fajardo, C. M. [3] ; Hirata, R. D. C. [3] ; Almeida, M. G. [1] ; Hirata, M. H. [3] ; Rezende, A. A. [1]
Número total de Autores: 14
Afiliação do(s) autor(es):
[1] Univ Fed Rio Grande do Norte, Dept Clin & Toxicol Anal, Sch Pharmaceut Sci, BR-59072970 Natal, RN - Brazil
[2] Univ Fed Rio Grande do Norte, Pediat Hosp Prof Heriberto Bezerra, Care Programme Children Cleft Lip & Palate, BR-59072970 Natal, RN - Brazil
[3] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: ORAL DISEASES; v. 19, n. 5, p. 507-512, JUL 2013.
Citações Web of Science: 17
Resumo

OBJECTIVE: The aim of this study was to investigate the contribution of 6 polymorphic variants of the MSX1 gene in non-syndromic cleft lip and/or palate (NSCL/P). METHODS: Three hundred and fifty-eight individuals (158 NSCL/P cases and 200 controls) were genotyped by TaqMan allelic discrimination using predesigned SNP assays. Statistical analyses were conducted using the software SPSS 15.0 and the R statistical suite. Haplotype block structure and haplotype frequencies were determined using the Haploview. A P-value of 0.05 and confidence interval of 95% were used for all of statistical tests. RESULTS: The patients with non-syndromic cleft lip and/or palate were characterized by similar distribution of MSX1 genotypes and allele in comparison to subjects without oral clefts (P > 0.05). Two haplotype blocks were constructed with polymorphisms of MSX1 gene and haplotypes formed showed a similar frequency in patients with and without oral clefts. CONCLUSIONS: The present study provides no evidence that MSX1 polymorphisms (rs3775261, rs1042484, rs12532, rs6446693, rs4464513 and rs1907998) play a major role in NSCL/P. (AU)

Processo FAPESP: 08/05064-9 - Avaliação de polimorfismos genéticos associados ao metabolismo do ácido fólico e ao desenvolvimento facial em crianças portadoras de fendas orais no estado do RN
Beneficiário:Mario Hiroyuki Hirata
Linha de fomento: Auxílio à Pesquisa - Regular