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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Pueraria tuberosa DC Extract Improves Androgenesis and Sexual Behavior via FSH LH Cascade

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Autor(es):
Chauhan, Nagendra Singh [1] ; Sharma, Vikas [1] ; Thakur, Mayank [2] ; Sawaya, Alexandra Christine Helena Frankland [3] ; Dixit, V. K. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Dr HS Gour Vishwavidyalaya, Dept Pharmaceut Sci, Sagar 470003, Madhya Pradesh - India
[2] Charite Campus Benjamin Franklin, Cent Inst Lab Med, D-12200 Berlin - Germany
[3] Univ Estadual Campinas, Inst Biol, Dept Plant Biol, BR-13083970 Campinas, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: SCIENTIFIC WORLD JOURNAL; 2013.
Citações Web of Science: 9
Resumo

The aim of this study was to investigate the effects of ethanolic extract of Pueraria tuberosa (PT) on sexual behaviour and androgenic activity. Male albino rats were divided into four groups of six animals each: control group 1 (2% acacia solution), PT-treated group 2 (50 mg/Kg), PT-treated group 3 (100 mg/Kg), and PT-treated group 4 (150 mg/Kg). Sexual behavior of male rats in the presence of a female rat was recorded. The treated groups were evaluated for sexual parameters. The extract was characterized using LC-MS. The effect of treatment on anabolic and weight of secondary sexual organs was determined. The histological changes in section of testis and epididymis after treatment were observed. Sperm count in epididymis and fructose content in seminal vesicles were also measured. Levels of hormones like FSH, LH, and T were determined. A dose-dependent increase in sexual behaviors was evidenced in the animals of extract treated groups. Increase in testis weight was recorded in PT. At the highest dose PT also affects the hormones level. The four compounds namely puerarin, daidzein, biochanin-A and formononetin were identified in ethanolic extract using LC-MS. It concluded that PT extract possesses androgenic effect and it significantly increased the sexual behaviour and hormones level. (AU)

Processo FAPESP: 08/58035-6 - Control of lignin biosynthesis in sugar cane: many gaps still to be filled
Beneficiário:Paulo Mazzafera
Linha de fomento: Auxílio à Pesquisa - Programa BIOEN - Temático