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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Actions of oestradiol and progesterone on the prostate in female gerbils: reversal of the histological effects of castration

Texto completo
Autor(es):
Zanatelli, Marianna [1] ; Silva, Diego A. L. [1] ; Shinohara, Filipe Z. [1] ; Goes, Rejane M. [2] ; Santos, Fernanda C. A. [3] ; Vilamaior, Patricia S. L. [2] ; Taboga, Sebastiao R. [2]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Inst Biol, Dept Cell Biol, BR-13083970 Campinas, SP - Brazil
[2] Sao Paulo State Univ, Dept Biol, Lab Microscopy & Microanal, BR-15054000 Sao Paulo - Brazil
[3] Univ Fed Goias, Inst Biol Sci, Dept Morphol, BR-74001970 Goiania, Go - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: REPRODUCTION FERTILITY AND DEVELOPMENT; v. 26, n. 4, p. 540-550, 2014.
Citações Web of Science: 4
Resumo

The female prostate is a functionally active gland in several mammalian species, including humans and rodents. Investigations of prostate morphophysiology during the phases of the oestrous cycle have shown that the female prostate is influenced by fluctuations in serum concentrations of oestradiol (E2) and progesterone (P4). The aim of the present study was to evaluate the effect of combined prolonged administration of E2 and P4 on the prostate in ovariectomised female gerbils. Ovariectomy caused atrophy and decreased glandular secretory activity. Administration of E2 and P4 (0.1 mg kg(-1) diluted in 0.1 mL of mineral oil, every 48 h over 30 days) resulted in a recovery of overall prostate structure, as evidenced by increased epithelial height, mass and prostatic secretory activity, without leading the appearance of significant lesions. Evaluation of androgen receptor (AR) expression revealed increased immunoreactivity in the E2+P4-treated group. Immunostaining for oestrogen receptor (ER) alpha was decreased in the castrated groups, but increased in the group subjected to hormone treatment. There were no significant differences in ER beta immunoreactivity among the groups. Assessment of cell proliferation revealed greater immunoreactivity in the treated group. Together, the results indicate that the interaction between E2 and P4 may be responsible for maintaining female prostate gland histophysiology. (AU)

Processo FAPESP: 09/12688-1 - Aspectos morfofuncionais da próstata feminina do gerbilo durante o ciclo estral: efeitos da ovariectomia e posterior reposição prolongada pelo estradiol e progesterona
Beneficiário:Marianna Zanatelli
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 06/06876-1 - Aspectos morfofuncionais da próstata feminina do gerbilo durante o ciclo estral
Beneficiário:Sebastião Roberto Taboga
Linha de fomento: Auxílio à Pesquisa - Regular