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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Expression of MicroRNA-29 and Collagen in Cardiac Muscle after Swimming Training in Myocardial-Infarcted Rats

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Autor(es):
Melo, Stephano F. S. [1] ; Fernandes, Tiago [1] ; Barauna, Valerio G. [2] ; Matos, Katt C. [1] ; Santos, Alexandra A. S. [3] ; Tucci, Paulo J. F. [3] ; Oliveira, Edilamar M. [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Phys Educ & Sport, Dept Human Movement Biodynam, Lab Biochem & Mol Biol Exercise, Sao Paulo - Brazil
[2] Univ Fed Espirito Santo, Dept Physiol Sci, Vitoria - Brazil
[3] Univ Fed Sao Paulo, Sch Med, Dept Physiol, Lab Cardiac Physiol, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY; v. 33, n. 3, p. 657-669, 2014.
Citações Web of Science: 44
Resumo

Background: Myocardial infarction (MI) is accompanied by cardiac growth, increased collagen deposition, cell death and new vascularization of the cardiac tissue, which results in reduced ventricular compliance. The MiRNA-29 family (29a, 29b, and 29c) targets mRNAs that encode collagens and other proteins involved in fibrosis. In this study we assessed the effects of swimming training (ST) on expression of the cardiac miRNA-29 family and on genes encoding collagen after MI in rats. Methods: ST consisted of 60 min/day/10 weeks and began four weeks after MI. MiRNA and collagen expression analysis were performed in the infarcted region (IR), border region (BR) of the infarcted region and in the remote myocardium (RM) of the left ventricle. Results: MiRNA-29a expression increased 32% in BR and 52% in RM in the TR-INF compared with SED-INF. MiRNA-29c increased by 63% in BR and 55% in RM in TR-INF compared with SED-INF group. COL IAI and COL IIIAI decreased by 63% and 62% in TR-INF, respectively, compared with SED-INF. COLIIIAI expression decreased by 16% in TR-INF compared with SED-INF. Conclusion: Altogether, our results showed that ST restores cardiac miRNA-29 (a and c) levels and prevents COL IAI and COL IIIAI expression in BR and RM, which may contribute to the improvement in ventricular function induced by swimming training, after MI. Copyright (C) 2014 S. Karger AG, Basel (AU)

Processo FAPESP: 09/18370-3 - Expressão de microRNAs no coração de ratos normotensos submetidos a diferentes volumes de treinamento físico aeróbico e seu potencial terapêutico na hipertensão
Beneficiário:Edilamar Menezes de Oliveira
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 10/09438-0 - Utilização terapêutica de microRNAs responsáveis pela regulação da contratilidade cardíaca associado ao treinamento físico aeróbico em ratos com insuficiência cardíaca
Beneficiário:Stéphano Freitas Soares Melo
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 10/50048-1 - Bases celulares e funcionais do exercício físico na doença cardiovascular
Beneficiário:Carlos Eduardo Negrão
Linha de fomento: Auxílio à Pesquisa - Temático