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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Delayed reproductive development in pubertal male rats exposed to the hypolipemiant agent rosuvastatin since prepuberty

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Autor(es):
Araujo Leite, Gabriel Adan [1] ; Rosa, Josiane de Lima [1] ; Sanabria, Marciana [1] ; Cavariani, Marilia Martins [1] ; Anselmo Franci, Janete Aparecida [2] ; Felipe Pinheiro, Patricia Fernanda [3] ; Kempinas, Wilma De Grava [4]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] UNESP, Inst Biociencias, Grad Program Gen & Appl Biol, BR-18618970 Botucatu, SP - Brazil
[2] Univ Sao Paulo, Sch Dent, Dept Morphol Stomatol & Physiol, BR-14049 Ribeirao Preto, SP - Brazil
[3] UNESP, Inst Biociencias, Dept Anat, BR-18618970 Botucatu, SP - Brazil
[4] UNESP, Inst Biociencias, Dept Morfol, BR-18618970 Botucatu, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: REPRODUCTIVE TOXICOLOGY; v. 44, p. 93-103, APR 2014.
Citações Web of Science: 16
Resumo

Dyslipidemias are frequently found in children due to obesity, bad eating habits and the lack of physical exercises. Rosuvastatin acts as an HMG-CoA reductase inhibitor, decreasing total cholesterol and triglycerides. This study aimed to investigate initial sexual development and morphological aspect of the testis and epididymis in juvenile rats exposed to rosuvastatin since pre-puberty. Three groups were formed with newly weaned rats: control, whose rats received saline solution 0.9%, rosuvastatin at doses of 3 or 10 mg/kg daily by gavage, since post-natal day 21 until puberty onset. In the rosuvastatin-treated groups, the results demonstrated a trend toward a decrease in testosterone concentration, but below the significance level, as well as delays in both the age of puberty onset and in epididymal development. There were also testicular alterations that might be related to delayed puberty and decrease of serum testosterone. In conclusion, rosuvastatin administration to juvenile rats not only delayed puberty onset and epididymal development, but also impaired testicular and epididymal morphology. (C) 2014 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 11/15065-5 - Desenvolvimento reprodutivo de ratos machos expostos ao agente lipolipemiante rosuvastatina
Beneficiário:Gabriel Adan Araújo Leite
Linha de fomento: Bolsas no Brasil - Mestrado