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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The Effect of Different Photoperiods in Circadian Rhythms of Per3 Knockout Mice

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Autor(es):
Pereira, D. S. [1] ; van der Veen, D. R. [2] ; Goncalves, B. S. B. [3, 4] ; Tufik, S. [1] ; von Schantz, M. [2] ; Archer, S. N. [2] ; Pedrazzoli, M. [5]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo UNIFESP, Dept Psicobiol, BR-04024002 Sao Paulo - Brazil
[2] Univ Surrey, Fac Hlth & Med Sci, Guildford GU2 5XH, Surrey - England
[3] Univ Fed Rio Grande do Norte, UFRN, Dept Fisiol, BR-59072970 Natal, RN - Brazil
[4] Inst Fed Sudeste Minas Gerais, Barbacena, MG - Brazil
[5] Univ Sao Paulo, Escola Artes Ciencias & Humanidades, Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: BIOMED RESEARCH INTERNATIONAL; 2014.
Citações Web of Science: 3
Resumo

The aim of this study was to analyse the circadian behavioural responses of mice carrying a functional knockout of the Per3 gene (Per3(-/-)) to different light : dark (L : D) cycles. Male adult wild- type (WT) and Per3(-/-) mice were kept under 12- hour light : 12hour dark conditions (12L : 12D) and then transferred to either a short or long photoperiod and subsequently released into total darkness. All micewere exposed to both conditions, and behavioural activity datawere acquired through runningwheel activity and analysed for circadian characteristics during these conditions. We observed that, during the transition from 12L : 12D to 16L : 8D, Per3(-/-)mice take approximately one additional day to synchronise to the new L : D cycle compared toWT mice. Under these long photoperiod conditions, Per3(-/-) mice were more active in the light phase. Our results suggest that Per3(-/-) mice are less sensitive to light. The data presented here provides further evidence that Per3 is involved in the suppression of behavioural activity in direct response to light. (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 07/05037-9 - Caracterização fenotipica de camundongos knock-out e knock-in do gene PER3 em diferentes fotoperíodos
Beneficiário:Danyella Silva Pereira
Linha de fomento: Bolsas no Brasil - Doutorado