m1 Acetylcholine Receptor Expression is Decreased in Hippocampal CA1 region of Aged Epileptic Animals

Autor(es)

Cavarsan, Clarissa Fantin ^[1] ; Avanzi, Renata Della Torre ^[1] ; Queiroz, Claudio Marcos ^[2] ; Xavier, Gilberto Fernando ^[3] ; Mello, Luiz Eugenio ^[1] ; Covolan, Luciene ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo - Brazil

^[2] Univ Fed Rio Grande do Norte, Inst Brain, BR-59072970 Natal, RN - Brazil

^[3] Univ Sao Paulo, Biosci Inst, Dept Physiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Aging and disease; v. 2, n. 4, p. 301-307, AUG 2011.
• Citações Web of Science: 10

Resumo

In the present study, we investigated the possible additive effects of epilepsy and aging on the expression of m1 muscarinic acetylcholine receptors (AChR) in the rat hippocampus. Young (3 months) and Aged (20 months) male, Wistar rats were treated with pilocarpine to induce status epilepticus (SE). Immunohistochemical procedure for m1 AChR detection was performed 2 months after pilocarpine-induced SE. In the CA1 pyramidal region m1 AChR staining was significantly decreased in aged epileptic animals when compared to young epileptic and aged control rats, indicating that the aging effect is worsened by the epileptic condition. However, the Nissl-stained cell analysis indicated that the number of pyramidal CA1 neurons was similarly reduced in both epileptic groups, young and aged animals. Therefore, our data suggest that the progressive reduction of m1 AChR expression in CA1 pyramidal cells of aged epileptic rats might bear relevance to the associated progressive cognitive impairment. (AU)

• Processo FAPESP: 06/60256-5 - Avaliação da relação entre aprendizagem e memória, neurogênese e envelhecimento, em animais epilépticos crônicos utilizando o modelo da pilocarpina
• Beneficiário: Luciene Covolan
• Modalidade de apoio: Auxílio à Pesquisa - Regular