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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Can Wistar rats be used as the normotensive controls for nerve morphometry investigations in spontaneously hypertensive rats (SHR)?

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Autor(es):
Sanada, Luciana Sayuri [1] ; Tavares, Marcelo Rodrigo [2] ; Maia Neubern, Milena Cardoso ; Salgado, Helio Cesar [3] ; Sassoli Fazan, Valeria Paula [4]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] USP, FMRP, Dept Neurosci & Behav Neurosci, Ribeirao Preto, SP - Brazil
[2] Univ Jose do Rosario Velano, UNIFENAS, Phys Educ Course, Alfenas, MG - Brazil
[3] USP, FMRP, Dept Physiol, Ribeirao Preto, SP - Brazil
[4] USP, FMRP, Dept Surg & Anat, Microscopy & Morphometry Lab, Ribeirao Preto, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Acta Cirurgica Brasileira; v. 26, n. 6, p. 514-520, NOV-DEC 2011.
Citações Web of Science: 3
Resumo

PURPOSE: We compared the sural nerve morphology among Wistar (WR), Wistar-Kyoto (WKY) and Spontaneously hypertensive (SHR) rats, including the nerve fascicles and myelinated fibers morphometry. METHODS: Age matched (20 weeks) female WR (N=6), WKY (N=6) and SHR (N=7) had their right and left sural nerves removed, embedded in epoxy resin, and observed by light microscopy. Morphometric analysis was performed with the aid of computer software. RESULTS: Despite presenting the same age, WR were heavier than WKY and SHR, as were SHR compared to WKY. Systolic arterial pressure was higher in SHR compared to WR, but no differences between SHR and WKY or WR and WKY were observed. The sural nerves were morphometrically symmetric between proximal and distal segments on the same side and between sides in all strains with no differences in the myelinated fiber number. Schwann cell number and density were smaller in SHR and G ratio was larger in SHR, indicating that SHR have thinner myelinated fibers. CONCLUSION: Sural nerve morphology is similar between WKY and WR, allowing the use of WR as the SHR controls in morphological investigations involving peripheral neuropathies. (AU)

Processo FAPESP: 09/50389-6 - Regulação cardiocirculatória em condições fisiológicas e fisiopatológicas
Beneficiário:Helio Cesar Salgado
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 10/12518-6 - Avaliação morfológica e comparação dos tipos de fibras dos músculos gastrocnêmios lateral e medial e flexor longo do hálux após estimulação dolorosa no período neonatal
Beneficiário:Valéria Paula Sassoli Fazan
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/16748-9 - Avaliação morfológica e morfométrica do nervo frênico de ratos espontaneamente hipertensos em diferentes fases do desenvolvimento
Beneficiário:Valéria Paula Sassoli Fazan
Linha de fomento: Auxílio à Pesquisa - Regular