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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Cervicovaginal Levels of Proinflammatory Cytokines Are Increased During Chlamydial Infection in Bacterial Vaginosis But Not in Lactobacilli-Dominated Flora

Autor(es):
Marconi, Camila [1] ; Santos-Greatti, Mariana M. V. [1] ; Parada, Cristina M. G. L. [2] ; Pontes, Anagloria [3] ; Pontes, Ana G. [3] ; Giraldo, Paulo C. [4] ; Donders, Gilbert G. G. [5] ; da Silva, Marcia Guimaraes [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] UNESP Univ Estadual Paulista, Botucatu Med Sch, Dept Pathol, Campinas, SP - Brazil
[2] UNESP Univ Estadual Paulista, Botucatu Med Sch, Dept Nursing, Campinas, SP - Brazil
[3] UNESP Univ Estadual Paulista, Botucatu Med Sch, Dept Gynecol & Obstet, Campinas, SP - Brazil
[4] Univ Estadual Campinas, Fac Ciencias Med, Dept Gynecol & Obstet, Campinas, SP - Brazil
[5] Univ Hosp Gasthuisberg, Leuven - Belgium
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF LOWER GENITAL TRACT DISEASE; v. 18, n. 3, p. 261-265, JUL 2014.
Citações Web of Science: 10
Resumo

Objective. The purpose of this study was to assess the cervicovaginal levels of proinflammatory cytokines in women with Chlamydia trachomatis (CT) infection in the presence of bacterial vaginosis (BV) and normal flora and to compare with those negative for CT. Materials and Methods. In this cross-sectional study, nonpregnant women were enrolled at 2 outpatient clinics and at 1 primary medical care unit in Sao Paulo State, Brazil. Cervicovaginal samples from 256 women with BV, of which 68 (26.6%) had concomitant CT infection and 188 (73.4%) were CT-negative, were measured for interleukin-1 beta (IL-1 beta), IL-6, and IL-8 by enzyme-linked immunosorbent assay. A matching number of samples from women with normal flora, CT-positive (n = 68) and negative (n = 188), were evaluated as control. Cytokine levels were compared by Mann-Whitney test and differences were considered significant at p < .05. Results. In CT-negative women, IL-1 beta was increased in BV (p < .001) when compared to normal flora, while the levels of IL-6 and IL8 were unchanged. The presence of CT infection was not associated with differences on cytokine levels in women with normal flora. However, women with BV had higher levels of IL-1 beta (p = .02), IL-6 (p = .02), and IL-8 (p = .03) in the presence of CT when compared to those who tested negative for CT. Conclusions. Detection of endocervical CT is associated with increased cervicovaginal IL-1 beta, IL-6, and IL-8 levels in women with concomitant BV but not in those with normal flora. (AU)

Processo FAPESP: 09/50560-7 - Aspectos clínicos, microbiológicos e da regulação da imunidade inata na vaginose bacteriana
Beneficiário:Márcia Guimarães da Silva
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/55420-6 - Aspectos clínicos, microbiológicos e da regulação da imunidade inata na vaginose bacteriana
Beneficiário:Camila Marconi
Linha de fomento: Bolsas no Brasil - Doutorado