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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Demographic Histories of ERV-K in Humans, Chimpanzees and Rhesus Monkeys

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Autor(es):
Romano, Camila M. [1] ; de Melo, Fernando L. [2] ; Corsini, Marco Aurelio B. [3] ; Holmes, Edward C. [4] ; Zanotto, Paolo M. de A. [5]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo. Biomed Sci Inst ICBII
[2] Univ Sao Paulo. Biomed Sci Inst ICBII
[3] Univ Sao Paulo. Biomed Sci Inst ICBII
[4] Penn State Univ. Dept Biol
[5] Univ Sao Paulo. Biomed Sci Inst ICBII
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: PLoS One; v. 2, n. 10 OCT 10 2007.
Citações Web of Science: 9
Resumo

We detected 19 complete endogenous retroviruses of the K family in the genome of rhesus monkey (Macaca mulatta; RhERV-K) and 12 full length elements in the genome of the common chimpanzee (Pan troglodytes; CERV-K). These sequences were compared with 55 human HERV-K and 20 CERV-K reported previously, producing a total data set of 106 full-length ERV-K genomes. Overall, 61% of the human elements compared to 21% of the chimpanzee and 47% of rhesus elements had estimated integration times less than 4.5 million years before present (MYBP), with an average integration times of 7.8 MYBP, 13.4 MYBP and 10.3 MYBP for HERV-K, CERV-K and RhERV-K, respectively. By excluding those ERV-K sequences generated by chromosomal duplication, we used 63 of the 106 elements to compare the population dynamics of ERV-K among species. This analysis indicated that both HERV-K and RhERV-K had similar demographic histories, including markedly smaller effective population sizes, compared to CERV-K. We propose that these differing ERV-K dynamics reflect underlying differences in the evolutionary ecology of the host species, such that host ecology and demography represent important determinants of ERV-K dynamics. (AU)

Processo FAPESP: 00/04205-6 - Projeto VIRGEN - Viral Genetic Diversity Network (VGDN)
Beneficiário:Paolo Marinho de Andrade Zanotto
Linha de fomento: Auxílio à Pesquisa - Regular