Demographic Histories of ERV-K in Humans, Chimpanzees and Rhesus Monkeys

Autor(es)

Romano, Camila M. ^[1] ; de Melo, Fernando L. ^[2] ; Corsini, Marco Aurelio B. ^[3] ; Holmes, Edward C. ^[4] ; Zanotto, Paolo M. de A. ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo. Biomed Sci Inst ICBII

^[2] Univ Sao Paulo. Biomed Sci Inst ICBII

^[3] Univ Sao Paulo. Biomed Sci Inst ICBII

^[4] Penn State Univ. Dept Biol

^[5] Univ Sao Paulo. Biomed Sci Inst ICBII

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 2, n. 10 OCT 10 2007.
• Citações Web of Science: 9

Resumo

We detected 19 complete endogenous retroviruses of the K family in the genome of rhesus monkey (Macaca mulatta; RhERV-K) and 12 full length elements in the genome of the common chimpanzee (Pan troglodytes; CERV-K). These sequences were compared with 55 human HERV-K and 20 CERV-K reported previously, producing a total data set of 106 full-length ERV-K genomes. Overall, 61% of the human elements compared to 21% of the chimpanzee and 47% of rhesus elements had estimated integration times less than 4.5 million years before present (MYBP), with an average integration times of 7.8 MYBP, 13.4 MYBP and 10.3 MYBP for HERV-K, CERV-K and RhERV-K, respectively. By excluding those ERV-K sequences generated by chromosomal duplication, we used 63 of the 106 elements to compare the population dynamics of ERV-K among species. This analysis indicated that both HERV-K and RhERV-K had similar demographic histories, including markedly smaller effective population sizes, compared to CERV-K. We propose that these differing ERV-K dynamics reflect underlying differences in the evolutionary ecology of the host species, such that host ecology and demography represent important determinants of ERV-K dynamics. (AU)

• Processo FAPESP: 00/04205-6 - Projeto VIRGEN - Viral Genetic Diversity Network (VGDN)
• Beneficiário: Paolo Marinho de Andrade Zanotto
• Linha de fomento: Auxílio à Pesquisa - Regular