Graphene and carbon nanotube composite enabling a new prospective treatment for trichomoniasis disease

Autor(es)

Zanin, H. ^[1] ; Margraf-Ferreira, A. ^[2] ; da Silva, N. S. ^[2] ; Marciano, F. R. ^[3] ; Corat, E. J. ^[1] ; Lobo, A. O. ^[3]

Afiliação do(s) autor(es)

^[1] Natl Inst Space Res, BR-12227010 Sao Jose Dos Campos, SP - Brazil

^[2] Univ Vale do Paraiba, Inst Res & Dev, Lab Cell Biol & Tissue, BR-12227010 Sao Jose Dos Campos, SP - Brazil

^[3] Univ Vale do Paraiba, Inst Res & Dev, Lab Biomed Nanotechnol, BR-12227010 Sao Jose Dos Campos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Materials Science & Engineering C-Materials for Biological Applications; v. 41, p. 65-69, AUG 1 2014.
• Citações Web of Science: 15

Resumo

We report the synthesis and application of novel graphene oxide and carbon nanotube oxide (GCN-O) composite. First, pristine multi-walled carbon nanotube was prepared by chemical vapour deposition furnace and then exfoliated and oxidised simultaneously by oxygen plasma etching. The superficial and volumetric compositions of GCN-O were measured by XPS spectroscopy and EDX spectroscopy, respectively. Both XPS and EDX analyses evidence that the GCN-O is composed of up to 20% of oxygen atoms. As a result, GCN-O forms a stable colloidal aqueous solution and shows to have strong interaction with the cell membrane of Tritrichomonas foetus protozoa, making easy its application as a drug carrier. Trichomoniasis infection of cattle is a devastating disease for cattle producers, causing some damages to females and fetus, and the abortion is the most serious result of this disease. There is no effective treatment for trichomoniasis infection yet. Therefore, new treatment, especially one with no collateral effects in animals, is required. With this goal in mind, our results suggest that water dispersible composite is a novel nanomaterial, promising for Trichomoniasis infection treatment and as therapeutic delivery agent as well. (C) 2014 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 11/20345-7 - Estudo de filmes de carbono-tipo diamante contendo nanopartículas incorporadas para aplicações biomédicas
• Beneficiário: Fernanda Roberta Marciano
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 08/06654-4 - Terapia fotodinâmica e ativação de morte celular no protozoário parasita do gado bovino Tritrichomonas foetus
• Beneficiário: Newton Soares da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/17877-7 - Desenvolvimento de novos scaffolds poliméricos por eletrofiação com incorporação de nanotubos alinhados e nanohidroxiapatita para regeneração óssea
• Beneficiário: Anderson de Oliveira Lobo
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores