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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Detection of Plasmodium falciparum and Plasmodium vivax subclinical infection in non-endemic region: implications for blood transfusion and malaria epidemiology

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Autor(es):
Maselli, Luciana M. F. [1, 2] ; Levy, Debora [1] ; Laporta, Gabriel Z. [3, 4] ; Monteiro, Aline M. [5] ; Fukuya, Linah A. [5] ; Ferreira-da-Cruz, Maria F. [6] ; Daniel-Ribeiro, Claudio T. [6] ; Dorlhiac-Llacer, Pedro E. [5] ; Sallum, Maria Anice M. [3] ; Bydlowski, Sergio P. [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med, Lab Genet & Mol Hematol LIM31, BR-05403000 Sao Paulo - Brazil
[2] Fundacao Prosangue, Hemoctr Sao Paulo, BR-05403000 Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, BR-01246904 Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Med, Lab Informat Med LIM01, BR-01246903 Sao Paulo - Brazil
[5] Univ Sao Paulo, Sch Med, Hosp Clin, Div Hematol, BR-05403000 Sao Paulo - Brazil
[6] Inst Osvaldo Cruz, Malaria Res Lab, BR-21045900 Rio De Janeiro, RJ - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: Malaria Journal; v. 13, JUN 6 2014.
Citações Web of Science: 22
Resumo

Background: In Brazil, malaria is endemic in the Amazon River basin and non-endemic in the extra-Amazon region, which includes areas of Sao Paulo state. In this state, a number of autochthonous cases of malaria occur annually, and the prevalence of subclinical infection is unknown. Asymptomatic infections may remain undetected, maintaining transmission of the pathogen, including by blood transfusion. In these report it has been described subclinical Plasmodium infection in blood donors from a blood transfusion centre in Sao Paulo, Brazil. Methods: In this cross-sectional study, representative samples of blood were obtained from 1,108 healthy blood donors at the Fundacao Pro-Sangue Hemocentro de Sao Paulo, the main blood transfusion centre in Sao Paulo. Malaria exposure was defined by the home region (exposed: forest region; non-exposed: non-forest region). Real-time PCR was used to detect Plasmodium falciparum and Plasmodium vivax. Subclinical malaria cases were geo-referenced. Results: Eighty-four (7.41%) blood donors tested positive for Plasmodium; 57 of these were infected by P. falciparum, 25 by P. vivax, and 2 by both. The prevalence of P. falciparum and P. vivax was 5.14 and 2.26, respectively. The overall prevalence ratio (PR) was 3.23 (95% confidence interval (CI) 2.03, 5.13); P. falciparum PR was 16.11 (95% CI 5.87, 44.21) and P. vivax PR was 0.47 (95% CI 0.2, 1.12). Plasmodium falciparum subclinical malaria infection in the Atlantic Forest domain was present in the mountain regions while P. vivax infection was observed in cities from forest-surrounded areas. Conclusions: The presence of Plasmodium in healthy blood donors from a region known as non-endemic, which is important in the context of transfusion biosafety, was described. Infected recipients may become asymptomatic carriers and a reservoir for parasites, maintaining their transmission. Furthermore, P. falciparum PR was positively associated with the forest environment, and P. vivax was associated with forest fragmentation. (AU)

Processo FAPESP: 09/53141-5 - Importância da detecção de malária subclínica em doadores de sangue em zona não-endêmica
Beneficiário:Sergio Paulo Bydlowski
Linha de fomento: Auxílio à Pesquisa - Pesquisa em Políticas Públicas para o SUS
Processo FAPESP: 11/20397-7 - Taxonomia morfológica e molecular e filogenia do subgênero Nyssorhynchus do gênero Anopheles (Diptera: Culicidae), com ênfase especial em Anopheles darlingi da Mata Atlântica
Beneficiário:Maria Anice Mureb Sallum
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/09939-5 - Compreensão dos efeitos da paisagem e da biodiversidade na dinâmica de transmissão de malária
Beneficiário:Gabriel Zorello Laporta
Linha de fomento: Bolsas no Brasil - Pós-Doutorado