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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Structural brain abnormalities are related to retinal nerve fiber layer thinning and disease duration in neuromyelitis optica spectrum disorders

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Autor(es):
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von Glehn, Felipe [1, 2] ; Jarius, Sven [3] ; Cavalcanti Lira, Rodrigo Pessoa [4] ; Alves Ferreira, Maria Carolina [4] ; Ribeiro von Glehn, Fadua H. [2] ; Costa e Castro, Stella Maris [4] ; Beltramini, Guilherme Coco [5, 2] ; Bergo, Felipe P. G. [2] ; Farias, Alessandro S. [1] ; Brandao, Carlos Otavio [1, 2] ; Wildemann, Brigitte [3] ; Damasceno, Benito P. [2] ; Cendes, Fernando [2] ; Santos, Leonilda M. B. [1] ; Yasuda, Clarissa Lin [2]
Número total de Autores: 15
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Dept Genet Evolut & Bioagents, Neuroimmunol Unit, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Dept Neurol, Lab Neuroimaging, Campinas, SP - Brazil
[3] Heidelberg Univ, Dept Neurol, Div Mol Neuroimmunol, D-69115 Heidelberg - Germany
[4] Univ Estadual Campinas, Dept Ophthalmol, Campinas, SP - Brazil
[5] Univ Estadual Campinas, Inst Phys Gleb Wataghin, Campinas, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: MULTIPLE SCLEROSIS; v. 20, n. 9, p. 1189-1197, AUG 2014.
Citações Web of Science: 27
Resumo

Background: Although aquaporin-4 (AQP4) is widely expressed in the human brain cortex, lesions are rare in neuromyelitis optica (NMO) spectrum disorders (NMOSD). Recently, however, several studies have demonstrated occult structural brain atrophy in NMO. Objective: This study aims to investigate magnetic resonance imaging (MRI) patterns of gray matter (GM) and white matter (WM) abnormalities in patients with NMOSD and to assess the visual pathway integrity during disease duration correlation of the retinal nerve fiber layer (RNFL) and pericalcarine cortex thickness. Methods: Twenty-one patients with NMOSD and 34 matched healthy controls underwent both high-field MRI (3T) high-resolution T1-weighted and diffusion-tensor MRI. Voxel-based morphometry, cortical analyses (Freesurfer) and diffusion-tensor imaging (DTI) analyses (TBSS-FSL) were used to investigate brain abnormalities. In addition, RNFL measurement by optic-coherence tomography (OCT) was performed. Results: We demonstrate that NMOSD is associated with GM and WM atrophy, encompassing more frequently the motor, sensory and visual pathways, and that the extent of GM atrophy correlates with disease duration. Furthermore, we demonstrate for the first time a correlation between RNFL and pericalcarine cortical thickness, with cortical atrophy evolving over the course of disease. Conclusions: Our findings indicate a role for retrograde and anterograde neurodegeneration in GM atrophy in NMOSD. However, the presence atrophy encompassing almost all lobes suggests that additional pathomechanisms might also be involved. (AU)

Processo FAPESP: 12/04565-0 - Estudo da função imunoreguladora da molécula HLA-G na esclerose múltipla e na encefalomielite experimental auto-imune
Beneficiário:Leonilda Maria Barbosa dos Santos
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/18728-5 - Estudo do padrão migratório, efetor e regulador dos Linfócitos T auto-reativos, previamente transduzidos com GFP, nas doenças desmielinizantes experimentais
Beneficiário:Alessandro dos Santos Farias
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores