Clinical and laboratory features of overlap syndromes of idiopathic inflammatory myopathies associated with systemic lupus erythematosus, systemic sclerosis, or rheumatoid arthritis

Autor(es)

Aguila, Lisbeth Aranbicia ^[1] ; Ugolini Lopes, Michelle Remiao ^[2] ; Pretti, Flavia Zon ^[3] ; Sampaio-Barros, Percival Degrava ^[4] ; Carlos de Souza, Fernando Henrique ^[5] ; Borba, Eduardo Ferreira ^[6] ; Shinjo, Samuel Katsuyuki ^[7]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo. Fac Med

^[2] Univ Sao Paulo. Fac Med

^[3] Univ Sao Paulo. Fac Med

^[4] Univ Sao Paulo. Fac Med

^[5] Univ Sao Paulo. Fac Med

^[6] Univ Sao Paulo. Fac Med

^[7] Univ Sao Paulo. Fac Med

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL RHEUMATOLOGY; v. 33, n. 8, p. 1093-1098, AUG 2014.
• Citações Web of Science: 0

Resumo

Because overlap syndromes (OSs) are rarely described, we analyzed retrospectively their frequencies and correlations in Brazilian series of 31 patients with dermatomyositis (DM)/polymyositis (PM) associated with systemic lupus erythematosus (SLE), systemic sclerosis (SSc), or rheumatoid arthritis (RA) attended at a referral single center. Myositis-specific autoantibodies (MSAs: anti-Jo-1, anti-PL-7, anti-PL-12, anti-EJ, anti-OJ, anti-SRP, anti-Mi-2) and myositis-associated autoantibodies (MAAs: anti-PM-Scl75, anti-PM-Scl100, anti-Ku) as well as specific autoantibodies related to SLE, SSc, and RA were investigated. The mean age of the OS patients (9 DM and 22 PM) was 44.6 +/- 15.4 years, with a predominance of women (83.9 %) and white ethnicity (58.1 %). PM was the most frequent inflammatory myopathy, and the clinical presentation of DM/PM was significantly different among the OS groups. Overlap was found with SSc (48.4 %), SLE (29.0 %), and RA (22.6 %). The clinical manifestations of DM/PM were identified simultaneously with SSc and RA in the majority of cases, in contrast to identification in the SLE group (p < 0.05). All patients were positive for antinuclear antibodies, and the prevalence of MSA and MAA was 38.8 % in all OS groups, mutually exclusive, and more frequent in the SSc group. Comparing the clinical and laboratory features, there was a higher frequency of vascular (skin ulcers, Raynaud's phenomenon) and pulmonary (interstitial lung disease) involvement in the SSc group (p < 0.05). Moreover, there were no differences among the groups in relation to disease relapse and deaths. Concluding, this is the first study to show the different characteristics of a series of patients with connective tissue disease (CTD)-OS in the heterogeneous Brazilian population. (AU)

• Processo FAPESP: 11/12700-1 - Perfil e prevalência de autoanticorpos miosite-específicos e miosite-associados na população brasileira com a dermatomiosite/polimiosite
• Beneficiário: Samuel Katsuyuki Shinjo
• Modalidade de apoio: Auxílio à Pesquisa - Regular