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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment

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Autor(es):
Moreli, Jusciele Brogin [1] ; Santos, Janine Hertzog [2] ; Rocha, Clarissa Ribeiro [3] ; Damasceno, Debora Cristina [1] ; Morceli, Glilciane [1] ; Rudge, Marilza Vieira [1] ; Bevilacqua, Estela [4] ; Paranhos Calderon, Iracema Mattos [1, 5]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ, Grad Program Gynecol Obstet & Mastol, UNESP, Sao Paulo - Brazil
[2] NIEHS, Mol Carcinogenesis Lab, Durham, NC - USA
[3] Univ Sao Paulo, Dept Microbiol, BR-05508 Sao Paulo - Brazil
[4] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo - Brazil
[5] Sao Paulo State Univ, Botucatu Med Sch, Dept Obstet & Gynecol, UNESP, BR-18618000 Botucatu, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo de Revisão
Fonte: BIOMED RESEARCH INTERNATIONAL; 2014.
Citações Web of Science: 12
Resumo

The increased production of reactive oxygen species (ROS) plays a key role in pathogenesis of diabetic complications. ROS are generated by exogenous and endogenous factors such as during hyperglycemia. When ROS production exceeds the detoxification and scavenging capacity of the cell, oxidative stress ensues. Oxidative stress induces DNA damage and when DNA damage exceeds the cellular capacity to repair it, the accumulation of errors can overwhelm the cell resulting in cell death or fixation of genome mutations that can be transmitted to future cell generations. These mutations can lead to and/or play a role in cancer development. This review aims at (i) understanding the types and consequences of DNA damage during hyperglycemic pregnancy; (ii) identifying the biological role of DNA repair during pregnancy, and (iii) proposing clinical interventions to maintain genome integrity. While hyperglycemia can damage the maternal genetic material, the impact of hyperglycemia on fetal cells is still unclear. DNA repair mechanisms may be important to prevent the deleterious effects of hyperglycemia both in mother and in fetus DNA and, as such, prevent the development of diseases in adulthood. Hence, in clinical practice, maternal glycemic control may represent an important point of intervention to prevent the deleterious effects of maternal hyperglycemia to DNA. (AU)

Processo FAPESP: 11/13562-1 - Lesões no DNA e capacidade de resposta celular de gestantes e recém-nascidos em regime de hiperglicemia de intensidade variada
Beneficiário:Jusciele Brogin Moreli
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 12/23296-0 - Danos no DNA nuclear e mitocondrial em gestantes e recém-nascidos com hiperglicemia de intensidade variada
Beneficiário:Jusciele Brogin Moreli
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 11/18240-2 - Associação entre estresse oxidativo, lesões no DNA e capacidade de resposta celular em gestantes e recém-nascidos sob regime de hiperglicemia de intensidade variada
Beneficiário:Iracema de Mattos Paranhos Calderon
Linha de fomento: Auxílio à Pesquisa - Regular