The agreement with the University of California San Diego (UCSD), United States, aims to implement scientific and technological cooperation between researchers from the State of São Paulo and from UCSD, through the funding of joint research projects.
Focal Cortical Dysplasia (FCD) represents the most prevalent cause of severe drug-resistant epilepsy in children. Despite the considerable progress in FCD diagnosis and surgical therapy, treatment of these patients remains a challenge. Our goal is to establish a human in vitro model of FCD using cortical organoids to recapitulate brain somatic mosaicism in FCD and to have a reliable model…
Focal cortical dysplasia (FCD) is a malformation of cortical development and its main clinical manifestation is intractable epilepsy. Despite the considerable progress in diagnosis and surgical therapy, treatment of these patients remains a challenge mainly due to surgical inaccessibility in eloquent cortex areas and the absence of etiology-specific anti-epileptic-drugs (AED). Furthermore…
The project emerged from a discussion between L. Caldas and C. Caffrey during the visit of Profa. Caldas in August 2016 to the Center for Discovery and Innovation in Parasitic Diseases (www.cdipd.org) at the University of California San Diego where Prof. Caffrey is a senior center director. During this visit, both PIs agreed to collaborate on the identification of new compounds against sc…
| 3 | Completed research grants |
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