graduation at Farmácia from Universidade de Uberaba (2010), master's at Química from Universidade Estadual Paulista Júlio de Mesquita Filho (2012) and doctorate at Pharmacy from Universidade Estadual Paulista Júlio de Mesquita Filho (2016). Has experience in Chemistry, acting on the following subjects: nanomedicina, quitosana, quality by design, análise térmica and química ambiental. (Source: Lattes Curriculum)
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Thermogelation is a functional attribute relevant to the efficacy, stability, and sensory acceptability of bioadhesive gels applied topically to the skin or mucosal tissues. This property is stabilized by supramolecular forces (e.g., hydrogen bonding, hydrophobic interactions) that are sensitive to temperature, such as those formed by micellar systems based on poloxamers (sol-gel transiti…
The market for innovative cosmetic and pharmaceutical products is growing and fundamentally dependent on the use of excipients with properties capable of conferring physical-chemical stability to the active ingredient and the finished product while also bringing benefits for cosmeceutical and/or therapeutic actions. In this aspect, materials such as poloxamers and amphiphilic meglumine sa…
Thermoresponsive polymers have been widely studied due to their biocompatibility and applicability in several biomedical areas. Poloxamer, a triblock copolymer, is one of the most explored due to its self-assembly capacity and temperature-dependent sol-gel transition, allowing the controlled local release of drugs. However, it does not present good mucoadhesiveness, so it is necessary to …
The development of analytical methods is essential to ensure product quality, optimize manufacturing processes, guarantee regulatory compliance, and enhance laboratory efficiency. Well-established methods contribute to innovation, consumer safety, cost reduction, and organizational success. However, some drug delivery systems, such as thermoresponsive supramolecular systems, still lack ad…
Currently, one of the main causes of fungal infections has been associated with Candida albicans, a microorganism present in normal microbiota. However, due to its opportunistic nature, these microorganisms can trigger infections, especially due to their ability to form biofilms on the skin and mucous membranes, as is the case with candidiasis. It is known that pomegranate fruit peels (Pu…
Carotenoids are organic compounds that have been widely studied for their potential health benefits due to their antioxidant properties, contributing to the prevention of various diseases, such as chronic non-communicable diseases, cataracts, diabetic retinopathy, age-related macular degeneration, obesity, hypertension arterial and age-related muscular disorders. However, its instability …
The most serious cases of COVID-19 are manifested by a state of pulmonary hyperinflammation caused by a cytokine storm, which occurs due to the infection of the lower airways by the SARS-CoV-2 virus. Under these conditions, diffuse alveolar damage leads to severe acute respiratory disease (SARS), with a high mortality rate. Mucus-modulating nanoparticles are potentially useful in the pulm…
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Carotenoids are organic compounds widely recognized for their potential health benefits, attributed to their antioxidant properties, which contribute to the prevention of several diseases. However, the instability and low bioavailability of these compounds when administered orally represent significant challenges to their therapeutic efficacy. In this context, the present study aims to de…
Currently, one of the main causes of fungal infections has been associated with Candida albicans, a yeast present in the normal microbiota. However, due to their opportunistic nature and their ability to form biofilms on mucous membranes, which can lead to cases of oral candidiasis, especially in immunocompromised patients. Ellagic acid (EA) is a natural polyphenol present in several plan…
Glioblastoma (GBM), the most malignant primary brain tumors, are characterized by highly aggressive and invasive growth throughout the brain that can be contributed to activating multiple oncogenic pathways including vascular endothelial growth factor (VEGF) signaling. The VEGF is the main factor involved in the pathological angiogenesis of GBM. The targeted therapy with the monoclonal an…
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