CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Faculdade de Ciências Farmacêuticas (FCFAR) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Holds a Bachelors degree in Biological Sciences from the University of São Paulo (1994), as well as a Masters (1998) and a PhD (2002) in Basic and Applied Immunology from the Ribeirão Preto Medical School, University of São Paulo (FMRP-USP). Completed a postdoctoral fellowship at the Faculty of Pharmaceutical Sciences of Ribeirão Preto (20032005) and a PRODOC-CAPES researcher in the Graduate Program in Basic and Applied Immunology at FMRP-USP (20062007). Subsequently completed a postdoctoral fellowship at the University of Michigan (20072009) in the Division of Pulmonary and Critical Care Medicine. Served as a Visiting Research Scholar in the Department of Pathology, Microbiology, and Immunology at Vanderbilt University Medical Center, Nashville (20192020). Currently an Associate Professor (MS-5.3) at the Faculty of Pharmaceutical Sciences of Araraquara, São Paulo State University (UNESP). Research focuses on cellular immunology, with particular emphasis on the role of metabolic pathways in the activation of dendritic cells and CD4#8314; T lymphocytes during the phagocytosis of apoptotic cells in infection and cancer models.Served as Coordinator of the Graduate Program in Biosciences and Biotechnology Applied to Pharmacy from 2021 to 2024, during which the program maintained a CAPES Concept 7 rating. Secretary-General of the Brazilian Society of Immunology (SBI) for the 20262027 term. (Source: Lattes Curriculum)
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The development of some autoimmune diseases has been associated with genetic pre-dispositions and the phenomenon of molecular mimicry initiated by pathogens due to previous infections. However, recent studies have shown that phagocytosis, by dendritic cells (DCs), of infected-apoptotic cells, a process called efferocytosis, can result in the activation of autoreactive T-cells clones. In t…
Comorbidities are one of the factors related to the development of more severe forms of asthma and tuberculosis. Both diseases are immuno-mediated (immunopathologies), characterized by exacerbation of pulmonary inflammation, but triggered by different effector mechanisms. The Subprojects contained in this proposal have a clear objective: to determine mechanisms that exacerbate pulmonary i…
Infectious conditions are characterized by intense migration of cells such as neutrophils and monocytes, to the infected tissue in an attempt to contain the bacterial proliferation. After the phagocytosis of microorganisms, these cells eventually die, resulting in an accumulation of infected apoptotic cells in the tissue. The phagocytosis of infected apoptotic cells, called efferocytosis,…
(Only some records are available in English at this moment)
Prostaglandin E2 (PGE2) is a lipid mediator produced by several cell types, exerting itseffector functions through autocrine and paracrine mechanisms. PGE2 synthesis canoccur constitutively and/or be induced via activating cyclooxygenase enzymes 1 and 2(COX-1 and COX-2), both under physiological conditions and in the context of infectionsor pathological processes. Previous studies have de…
Dendritic cells and macrophages are specialized phagocytes responsible for the removal of apoptotic bodies, a process known as efferocytosis, both under homeostatic conditions and in pathological contexts. Dendritic cells play a key role in the antitumor response by presenting tumor cell antigens to CD4/CD8 T lymphocytes. In the tumor microenvironment, the phagocytosis of non-immunogenic …
During cutaneous infection by methicillin-resistant Staphylococcus aureus (MRSA), neutrophils are recruited and phagocytose the bacteria for digestion, subsequently undergoing cell death. Infected apoptotic neutrophils in the skin can be phagocytosed by dendritic cells, Langerhans cells, and macrophages. Phagocytosis of apoptotic cells, termed efferocytosis, demands energy for cytoskeleta…
The phagocytosis of apoptotic cells (ACs), termed efferocytosis, is essential for maintaining immune tolerance and tissue homeostasis, and dendritic cells (DCs) and macrophages are the main cells involved in this process. DCs also play a fundamental role in the antitumor response through the presentation of tumor cell antigens to TCD4/TCD8 lymphocytes. Although tumor cells are resistant t…
The dynamic of immune cells to respond to foreign antigen while maintaining tolerance to self-antigens requires constant metabolic adaptation. Dendritic Cells (DC) play a crucial role in the recognition of pathogens as well as in the clearance of Apoptotic Cells (AC) during infection or injury. We have recently showed that the clearance of AC in the absence of an infection leads to tolero…
(Only some records are available in English at this moment)
The pathogenesis of Systemic lupus erythematosus (SLE) is coordinated by autoantibody production against nuclear and phospholipid antigens that play an essential role in tissue damage. However, CD4+ T cell activation has been recognized as a critical player in SLE pathogenesis. Many reports have shown that patients with SLE have an increased frequency of CD4+IL-17+ T cells, as well as hig…
Type 1 diabetes (T1D) is an autoimmune disease characterized by destruction of pancreatic beta cells and high glucose levels. Diabetes has been associated with several inflammatory complications: impaired antimicrobial function and poor chemotaxis of phagocytes have been associated with increased risk of infections. Staphylococcus aureus is a major cause of skin and soft tissue infections…
Phagocytosis of apoptotic cells (efferocytosis), promotes the synthesis of anti-inflammatory mediators relevant to differentiation of regulatory T cells (Treg) such as transforming growth factor (TGF-b), prostaglandin E2 (PGE2) and interleukin-10 (IL-10). However, the phagocytosis of infected apoptotic cells (infected-AC) carrying pathogen-associated molecular patterns (PAMP), elicits the…
(Only some records are available in English at this moment)