CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Faculdade de Medicina (FMB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Medicina Humana from Universidade Estadual Paulista Júlio de Mesquita Filho (1987), master's at Bases Gerais da Cirurgia e Cirurgia Experimental from Universidade Estadual Paulista Júlio de Mesquita Filho (1996) and doctorate at Ginecologia, Obstetrícia e Mastologia from Universidade Estadual Paulista Júlio de Mesquita Filho (1999). Has experience in Medicine, acting on the following subjects: doença trofoblástica gestacional, parto, mola hidatiforme, neoplasia trofoblástica gestacional and mola hidatiforme completa. (Source: Lattes Curriculum)
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Approximately 5% of patients with low-risk gestational trophoblastic neoplasia (GTN) experience relapse after the completion of chemotherapy and normalization of the human chorionic gonadotropin (hCG) biomarker. However, there is no consensus on additional consolidation chemotherapy cycles after normalization is achieved. Identifying clinical factors that predict relapse is important to …
Subproject 1: MicroRNAs (miRNAs) are small non-coding single stranded RNAs with important regulatory functions. While well-studied in cancer, less is known about the role of miRNAs in premalignant disease. Complete hydatidiform moles (CHM) are benign forms of gestational trophoblastic disease (GTD) that progress to gestational trophoblastic neoplasia (GTN) in up to 20% of cases; however, …
Background. Studies have shown varying clinical presentation and initial treatment (hysterectomy or uterine evacuation) for complete hydatidiform mole (CHM) in women of advanced age ( e 40 years). Reports on these patients' clinical characteristics and response to treatment in different socioeconomic regions are still lacking. Objectives. To assess and compare complete hydatidiform mole (…
Background: Complete molar pregnancies result after an abnormal fertilization event, leading to the development of placental tissue without the presence of a fetus. It is widely assumed that the development of gestational trophoblastic neoplasia (GTN) is biologically predetermined and intrinsic to complete hydatidiform mole (CHM). However, the underlying genetic mechanisms are still uncle…
(Only some records are available in English at this moment)
Introduction: Approximately 5% of patients with low-risk gestational trophoblastic neoplasia (GTN) experience relapse after the completion of chemotherapy and normalization of the human chorionic gonadotropin (hCG) biomarker. However, there is no consensus on additional consolidation chemotherapy cycles after normalization is achieved. Identifying clinical factors that predict relapse is …
Low-risk gestational trophoblastic neoplasia (GTN) can be effectively treated by chemotherapy with a single agent, which is usually methotrexate (MTX) associated with folinic acid (FA) as it is less toxic than MTX or actinomycin D alone. There are no studies comparing treatment outcomes among regional centers with different socioeconomic characteristics and different treatment settings. O…
Potentially life-threatening complications and maternal near miss events such as hemorrhage, pre-eclampsia with severe features, thyrotoxic crisis and respiratory failure may be associated with the late diagnosis of hydatidiform mole (HM). The hook effect, which produces a false negative pregnancy test despite high titers of serum human chorionic gonadotropin (hCG), is a contributing fact…
Background: The clinical status of patients with gestational trophoblastic disease (GTD) upon admission to specialized centers is significantly influenced by social and economic factors, as well as by barriers in access to health care providers, which are associated with advanced disease at presentation. In Brazil, a regionalization strategy has been adopted in order to facilitate access …
(Only some records are available in English at this moment)
Introduction: Low-risk gestational trophoblastic neoplasia (GTN) can be successfully treated with single agent chemotherapy, usually methotrexate (MTX) or actinomycin-D (actD). MTX associated with folinic acid (FA) is the most used treatment, as it is less toxic than MTX alone or actD as a single agent. Objective: To assess the efficacy and toxicity of two different schedules of 8-day MTX…
Although adolescents comprise 30% of all cases of hydatidiform mole, the influence of young age on the risk of GTN development after a molar pregnancy is still to be determined. Objectives: To assess complete hydatidiform mole (CHM) clinical characteristics and the riskfactors associated with the development of post-molar GTN in teenagers from North and SouthAmerica. Methods: Non-concurre…
| 1 / 1 | Ongoing grants |
| 11 / 9 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 10 / 7 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 25 / 20 | All research grants and scholarships |
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